Portal de investigación
Experience of the Spanish Group for Hematopoietic Transplantation (GETMON-GETH) in allogenic Hematopoietic stem cell Transplantation in Philadelphia acute lymphoblastic leukemia.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Galán Gómez V
- de la Fuente Regano, Lydia
- Rodríguez Villa A
- Díaz de Heredia Rubio C
- González Vicent M
- Badell Serra I
- Isabel Pascual Martínez A
- María Pérez Hurtado J
- López Duarte M
- Soledad Maldonado Regalado M
- Pérez-Martínez A
Grupos
Abstract
INTRODUCTION: Outcomes in patients diagnosed of acute lymphoblastic leukemia with Philadelphia chromosome (Ph-ALL) remains unfavourable compared to other subtypes of acute lymphoblastic leukemia despite improvements in drug treatments as well as advances in hematopoietic stem cell transplantation (HSCT). PATIENTS AND METHODS: The role of allogeneic HSCT in Ph-ALL patients has been analysed through a multicentric study where data belonging to 70 patients diagnosed of this entity in different centers that received HSCT between years 1998 and 2014, were reported by the Grupo Español de Trasplante Hematopoyético (GETH). RESULTS: The performance of HSCT from year 2004, in first complete remission (CR) status with thymoglobulin (ATG) based conditioning had a favorable impact on overall survival (OS). HSTC performance from year 2004, in first CR with ATG-based conditioning in addition to acute graft versus host disease (aGvHD) development, increased event free survival (EFS). Treatment with imatinib as well as undetectable minimal residual disease (MRD) prior to HSCT, combined with aGvHD, reduced risk of relapse (RR). Patient age less than 10 years when HSCT, first CR and ATG-based conditioning were associated to a lower transplant related mortality (TRM). CONCLUSIONS: Patients that could achieve first CR that also received ATG-based conditioning had a better OS and EFS, so HSCT should be considered for this group of patients.
Copyright © 2022 Asociación Española de Pediatría. Published by Elsevier España, S.L.U. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 2341-2879, 2341-2879
- Tipo:
- Article
- Páginas:
- 309-318
- PubMed:
- 35523687
Anales De Pediatria
Documentos
- No hay documentos
Filiaciones
Keywords
- Acute lymphoblastic leukemia; BCR/ABL; Cromosoma de Philadelphia; Enfermedad de injerto contra receptor; Graft versus host disease; Hematopoietic stem cell transplantation; Imatinib; Leucemia linfoblástica aguda; Philadelphia chromosome; Trasplante de progenitores hematopoyéticos
Cita
Galán V,de la Fuente L,Rodríguez A,Díaz de Heredia Rubio C,González M,Badell I,MARÍA J,Isabel Pascual Martínez A,María Pérez Hurtado J,López M,Soledad Maldonado Regalado M,Pérez A. Experience of the Spanish Group for Hematopoietic Transplantation (GETMON-GETH) in allogenic Hematopoietic stem cell Transplantation in Philadelphia acute lymphoblastic leukemia. An Pediatr (Engl Ed). 2022. 96. (4):p. 309-318.