1. Inicio
  2. Publicaciones
  3. Impact of Neuromyelitis Optica Spectrum Disorder on Quality of Life from the Patients' Perspective: An Observational Cross-Sectional Study

Impact of Neuromyelitis Optica Spectrum Disorder on Quality of Life from the Patients' Perspective: An Observational Cross-Sectional Study

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Meca-Lallana, Jose E.
  • Gomez-Ballesteros, Rocio
  • Forero, Lucia
  • Sepulveda, Maria
  • Calles, Carmen
  • Martinez-Gines, Maria L.
  • Gonzalez-Suarez, Ines
  • Boyero, Sabas
  • Romero-Pinel, Lucia
  • Sempere, Angel P.
  • Meca-Lallana, Virginia
  • Querol, Luis
  • Costa-Frossard, Lucienne
  • Prefasi, Daniel
  • Maurino, Jorge

Grupos

Abstract

INTRODUCTION: Neuromyelitis optica spectrum disorder (NMOSD) is associated with a reduced health-related quality of life (HRQoL). The purpose of this study was to describe the impact of NMOSD on HRQoL from the patients' perspective and its relationship with other disease factors. METHODS: An observational, cross-sectional study was conducted at 13 neuroimmunology clinics in Spain. Patients with NMOSD diagnosis (2015 Wingerchuk criteria) were included. The 29-item Multiple Sclerosis Impact Scale (MSIS-29) was used to assess the HRQoL. Different questionnaires were used to measure symptom severity, stigma, mood disorders, pain, fatigue, and difficulties in the workplace. Factors that impact HRQoL were identified by Spearman's correlation and multivariate linear regression analysis. RESULTS: Seventy-one patients were included (mean age 47.4 ± 14.9 years, 80.3% female, mean time since disease onset 9.9 ± 8.1 years). The median Expanded Disability Status Scale score was 3.0 (1.5-4.5). The mean (± SD) physical and psychological MSIS-29 sub-scores were 41.9 ± 16.8 and 20.9 ± 8.3, respectively. Fatigue and body pain were the most prevalent symptoms. Depressive symptoms were found in 44.3% (n = 31) of patients. The physical MSIS-29 dimension showed the highest correlation with symptom severity (? = 0.85584, p < 0.0001), whereas the highest correlations for psychological MSIS-29 dimension were pain, MSIS-29 physical dimension, and depression (? = 0.76487, 0.72779, 0.71380; p < 0.0001, respectively). Pain was a predictor of both dimensions of MSIS-29. CONCLUSION: Fatigue, pain, and depressive symptoms are frequent problems among patients with NMOSD, impacting on their quality of life. Assessment of patient-oriented outcomes may be useful to achieve a holistic approach, allowing early specific interventions.

© 2022. The Author(s).

Datos de la publicación

ISSN/ISSNe:
2193-8253, 2193-6536

Neurology And Therapy  SPRINGER LONDON LTD

Tipo:
Article
Páginas:
1-16
PubMed:
35524037
Factor de Impacto:
1,003 SCImago ℠
Cuartil:
Q2 SCImago ℠

Citas Recibidas en Web of Science: 6

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • Depression; Fatigue; Health-related quality of life; Neuromyelitis optica spectrum disorder; Patient-reported outcomes

Campos de Estudio

Cita

Compartir