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Renal Function Impact in the Prognostic Value of Galectin-3 in Acute Heart Failure

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Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Perez, Pedro Caravaca
  • Gonzalez-Juanatey, Jose R.
  • Nuche, Jorge
  • Matute-Blanco, Lucia
  • Serrano, Isabel
  • Martinez Selles, Manuel
  • Vazquez Garcia, Rafael
  • Gomez-Bueno, Manuel
  • Pascual Figal, Domingo
  • Crespo-Leiro, Maria G.
  • Garcia-Osuna, Alvaro
  • Ordonez-Llanos, Jordi
  • Cinca Cuscullola, Juan
  • Guerra, Jose M.
  • Delgado, Juan F.

Grupos

Abstract

INTRODUCTION: Galectin-3 (Gal-3) is an inflammatory marker associated with the development and progression of heart failure (HF). A close relationship between Gal-3 levels and renal function has been observed, but data on their interaction in patients with acute HF (AHF) are scarce. We aim to assess the prognostic relationship between renal function and Gal-3 during an AHF episode. MATERIALS AND METHODS: This is an observational, prospective, multicenter registry of patients hospitalized for AHF. Patients were divided into two groups according to estimated glomerular filtration rate (eGFR): preserved renal function (eGFR = 60 mL/min/1.73 m(2)) and renal dysfunction (eGFR <60 mL/min/1.73 m(2)). Cox regression analysis was performed to evaluate the association between Gal-3 and 12-month mortality. RESULTS: We included 1,201 patients in whom Gal-3 values were assessed at admission. The median value of Gal-3 in our population was 23.2 ng/mL (17.3-32.1). Gal-3 showed a negative correlation with eGFR (rho = -0.51; p < 0.001). Gal-3 concentrations were associated with higher mortality risk in the multivariate analysis after adjusting for eGFR and other prognostic variables [HR = 1.010 (95%-CI: 1.001-1.018); p = 0.038]. However, the prognostic value of Gal-3 was restricted to patients with renal dysfunction [HR = 1.010 (95%-CI: 1.001-1.019), p = 0.033] with optimal cutoff point of 31.5 ng/mL, with no prognostic value in the group with preserved renal function [HR = 0.990 (95%-CI: 0.964-1.017); p = 0.472]. CONCLUSIONS: Gal-3 is a marker of high mortality in patients with acute HF and renal dysfunction. Renal function influences the prognostic value of Gal-3 levels, which should be adjusted by eGFR for a correct interpretation.

Copyright © 2022 Caravaca Perez, González-Juanatey, Nuche, Matute-Blanco, Serrano, Martínez Selles, Vázquez García, Martínez Dolz, Gómez-Bueno, Pascual Figal, Crespo-Leiro, García-Osuna, Ordoñez-Llanos, Cinca Cuscullola, Guerra and Delgado.

Datos de la publicación

ISSN/ISSNe:
2297-055X, 2297-055X

Frontiers in Cardiovascular Medicine  FRONTIERS MEDIA SA

Tipo:
Article
Páginas:
861651-861651
PubMed:
35463785
Factor de Impacto:
1,443 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 12

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Keywords

  • acute heart failure (AHF); cardiorenal syndrome (CRS); galectin-3 (Gal-3); prognosis; renal function

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