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Phenotype and Distribution of Immature Neurons in the Human Cerebral Cortex Layer II

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Coviello, Simona
  • Gramuntell, Yaiza
  • Klimczak, Patrycja
  • Varea, Emilio
  • Blasco-Ibanez, Jose Miguel
  • Crespo, Carlos
  • Nacher, Juan

Abstract

This work provides evidence of the presence of immature neurons in the human brain, specifically in the layer II of the cerebral cortex. Using surgical samples from epileptic patients and post-mortem tissue, we have found cells with different levels of dendritic complexity (type I and type II cells) expressing DCX and PSA-NCAM and lacking expression of the mature neuronal marker NeuN. These immature cells belonged to the excitatory lineage, as demonstrated both by the expression of CUX1, CTIP2, and TBR1 transcription factors and by the lack of the inhibitory marker GAD67. The type II cells had some puncta expressing inhibitory and excitatory synaptic markers apposed to their perisomatic and peridendritic regions and ultrastructural analysis suggest the presence of synaptic contacts. These cells did not present glial cell markers, although astroglial and microglial processes were found in close apposition to their somata and dendrites, particularly on type I cells. Our findings confirm the presence of immature neurons in several regions of the cerebral cortex of humans of different ages and define their lineage. The presence of some mature features in some of these cells suggests the possibility of a progressively integration as excitatory neurons, as described in the olfactory cortex of rodents.

Copyright © 2022 Coviello, Gramuntell, Klimczak, Varea, Blasco-Ibañez, Crespo, Gutierrez and Nacher.

Datos de la publicación

ISSN/ISSNe:
1662-5129, 1662-5129

FRONTIERS IN NEUROANATOMY  Frontiers Media S.A.

Tipo:
Article
Páginas:
851432-851432
Factor de Impacto:
1,425 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 5

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Keywords

  • cerebral cortex; doublecortin; human brain; immature neurons; neurogenesis

Proyectos asociados

ESTUDIO POSAUTORIZACIÓN OBSERVACIONAL EUROPEO PARA EVALUAR LA UTILIZACIÓN Y LA SEGURIDAD DEL CITRATO DE CAFEÍNA (PEYONA®) EN EL TRATAMIENTO DE NEONATOS PREMATUROS.

Investigador Principal: PILAR SÁENZ GONZÁLEZ

CHI-CAF-2011-01 . 2012

ENSAYO CLINICO, MULTICENTRICO, CONTROLADO, ALEATORIZADO, ENMASCARADO PARA COMPARAR LA SEGURIDAD Y LA EFECTIVIDAD DE SURFAXIN (LUCINANTANT) FRENTE A CUROSURF EN LA PREVENCION Y TRATAMIENTO DEL SINDROME DE DISTRES RESPIRATORIO (SDR) EN NEONATOS PREMATUROS.

Investigador Principal: JOSE MANUEL ROQUES SERRADILLA

KL4-IRDS-02

ESTUDIO DE LOS FACTORES DE RIESGO ASOCIADOS A LAS EXTUBACIONES ACCIDENTALES

Investigador Principal: MARTA AGUAR CARRASCOSA

ACCEX

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