Smoking is associated with age at disease onset in Parkinson's disease.

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Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Rosas I
  • Morís G
  • Coto E
  • Blázquez-Estrada M
  • Suárez E
  • García-Fernández C
  • Martínez C
  • Herrera ID
  • Pérez-Oliveira S
  • Álvarez V
  • Menéndez-González M
  • Spain_PD consortium
  • Adarmes-Gómez AD
  • Aguilar M
  • Alvarez I
  • Barrero FJ
  • Bergareche Yarza JA
  • Bonilla-Toribio M
  • Botía JA
  • Boungiorno MT
  • Buiza-Rueda D
  • Cámara A
  • Carrillo F
  • Cerdan D
  • Clarimón J
  • Compta Y
  • Diez-Fairen M
  • Dols-Icardo O
  • de Fabregues O
  • Cartagena PS
  • Duarte J
  • Duran R
  • Escamilla-Sevilla F
  • Ezquerra M
  • Feliz C
  • Fernández-Santiago R
  • Fernández M
  • García-Ruiz P
  • Gómez-Garre P
  • Gomez Heredia MJ
  • Gonzalez-Aramburu I
  • Gorostidi A
  • Hoenicka J
  • Infante J
  • Jesús S
  • Jimenez-Escrig A
  • Kulisevsky J
  • Labrador-Espinosa MA
  • Lopez-Sendon JL
  • López de Munain A
  • Macias-Garcia D
  • Marín J
  • Marti MJ
  • Martínez-Castrillo JC
  • Álvarez-Santullano MM
  • Mínguez-Castellanos A
  • Mir P
  • Rezola EM
  • Muñoz E
  • Pagonabarraga J
  • Pastor P
  • Errazquin FP
  • Periñán MT
  • Ruiz-Martínez J
  • Ruz C
  • Rodriguez AS
  • Sierra M
  • Tabernero C
  • Tartari JP
  • Tolosa E
  • Valldeoriola F
  • Vela L
  • Vives F
  • Pascual-Sedano B
  • Hernández-Vara J
  • Rolán DV
  • Bandrés-Ciga S

Abstract

BACKGROUND: Previous studies linked disease-progression variables such as age at onset or survival to both genetic, and non-genetic factors in Parkinson's disease (PD) patients. OBJECTIVE: The aim of this study was to assess how genetic and non genetic factors act as modifiers of age at onset and survival and in a cohort of 753 PD patients, and to determine how these variables interact to define the overall risk. METHODS: We analyzed the effect of gender, tobacco, alcohol, type of PD (genetic, gPD or idiopathic, iPD) and three genetic variants rs5848- GRN, rs1042522- TP53 and APOE. We studied two cohorts (PPMI and IPDGC) to replicate positive results. RESULTS: Regarding age at onset, male smokers PD had a significantly lower mean age compared to non-smoker (p = 0.001). APOE-?4 carriers had a younger onset-age compared to non-carriers (p = 0.03) in the Spanish cohort, but these results were not replicated in the other cohorts. Concerning survival, PD patients with an early onset (below 50 years) had an increased survival rate (p < 0.001). CONCLUSIONS: Our study showed how several genetic and non-genetic risk factors influenced the age at onset and survival in PD.

Copyright © 2022 Elsevier Ltd. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
1353-8020, 1873-5126

PARKINSONISM & RELATED DISORDERS  ELSEVIER SCI LTD

Tipo:
Article
Páginas:
79-83
PubMed:
35364453
Factor de Impacto:
1,093 SCImago
Cuartil:
Q1 SCImago

Citas Recibidas en Web of Science: 5

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Keywords

  • APOE; Age of onset; Parkinson disease; Smoking

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