1. Inicio
  2. Publicaciones
  3. Impact of Gestational COVID-19 on Neonatal Outcomes: Is Vertical Infection Possible?

Impact of Gestational COVID-19 on Neonatal Outcomes: Is Vertical Infection Possible?

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Vigil-Vazquez, Sara
  • Carrasco-Garcia, Itziar
  • Hernanz-Lobo, Alicia
  • Manzanares, Angela
  • Perez-Perez, Alba
  • Toledano-Revenga, Javier
  • Muñoz-Chapuli M
  • Mesones-Guerra, Lara
  • Martinez-Lozano, Andrea
  • Perez-Seoane, Beatriz
  • Marquez-Isidro, Elena
  • Sanz-Asin, Olga
  • Caro-Chinchilla, Gloria
  • Sarda-Sanchez, Marta
  • Lopez-Carnero, Juan
  • Pareja-Leon, Marta
  • Riaza-Gomez, Monica
  • Ortiz-Barquero MC
  • León-Luis JA
  • Fernández-Aceñero MJ
  • Muñoz-Fernández MÁ
  • Catalan-Alonso, Pilar
  • Muñoz-García P
  • Sanchez-Luna, Manuel
  • Navarro-Gómez ML

Grupos

Abstract

BACKGROUND: The vertical transmission of severe acute respiratory coronavirus-2 (SARS-CoV-2) remains highly debated. Here, we evaluated SARS-CoV-2-transmission in newborns with intrauterine conditions. METHODS: This was a prospective, observational and multicentric study involving 13 Spanish hospitals included in the GEStational and NEOnatal-COVID cohort. Pregnant women with microbiologically confirmed SARS-CoV-2 infection during any trimester of pregnancy or delivery and their newborns were included from March to November 2020. Demographic, clinical and microbiological data were also obtained. Viral loads were analyzed in different maternal and newborn biological samples (placenta, breast milk and maternal blood; urine, meconium and newborn blood). RESULTS: A total of 177 newborns exposed to SARS-CoV-2 were included. Newborns were tested by reverse transcriptase-polymerase chain reaction using nasopharyngeal swabs within the first 24-48 hours of life and at 14 days of life. In total 5.1% were considered to have SARS-CoV-2 infection in the neonatal period, with 1.7% considered intrauterine and 3.4% intrapartum or early postnatal transmission cases. There were no differences in the demographic and clinical characteristics of the pregnant women and their newborns' susceptibility to infections in their perinatal history or background. CONCLUSIONS: Intrauterine transmission of SARS-CoV-2 is possible, although rare, with early postnatal transmission occurring more frequently. Most infected newborns remained asymptomatic or had mild symptoms that evolved well during follow-up. We did not find any maternal characteristics predisposing infants to neonatal infection. All infected newborn mothers had acute infection at delivery.Although there was no presence of SARS-CoV2 in cord blood or breast milk samples, SARS-CoV-2 viral load was detected in urine and meconium samples from infected newborns.

Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0891-3668, 1532-0987

PEDIATRIC INFECTIOUS DISEASE JOURNAL  LIPPINCOTT WILLIAMS & WILKINS

Tipo:
Article
Páginas:
466-472
PubMed:
35363644
Factor de Impacto:
1,104 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 21

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • gestational SARS-CoV-2 infection; neonatal COVID-19; vertical transmission; placenta; breast milk

Compartir