A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.

Autores de IIS La Fe

• 

  Pilar Nos Mateu

  Autor

• María Andreu Fenoll

  Autor

Participantes ajenos a IIS La Fe

• Julià A
• Domènech E
• Ricart E
• Tortosa R
• García-Sánchez V
• Gisbert JP
• Gutiérrez A
• Gomollón F
• Mendoza JL
• Garcia-Planella E
• Barreiro-de Acosta M
• Muñoz F
• Vera M
• Saro C
• Esteve M
• Alonso A
• López-Lasanta M
• Codó L
• Gelpí JL
• García-Montero AC
• Bertranpetit J
• Absher D
• Panés J
• Marsal S

Grupos

• Enfermedad Inflamatoria Intestinal

Abstract

Genome-wide association studies (GWAS) have identified multiple risk loci for Crohn's disease (CD). However, the cumulative risk exerted by these loci is low, and the likelihood that additional, as-yet undiscovered loci contribute to the risk of CD is very high. We performed a GWAS on a southern European population to identify new CD risk loci.

Keywords

• Crohn's Disease, Genetic Polymorphisms, Genetics