Immunotherapy in Advanced Prostate Cancer: Current Knowledge and Future Directions.

Fecha de publicación: 24/02/2022 Fecha Ahead of Print: 24/02/2022

Autores de IIS La Fe

Antonio Conde Moreno

Autor

Participantes ajenos a IIS La Fe

Lopez-Campos, Fernando
Gajate, Pablo
Romero-Laorden, Nuria
Zafra-Martin, Juan
Juan, Manel
Hernando Polo, Susana
Couñago F

Grupos

Investigación Clínica y Traslacional en Cáncer

Leader

José Gómez Codina

Abstract

The advent of immunotherapy has revolutionized cancer treatment. Unfortunately, this has not been the case for metastatic castration-resistant prostate cancer (mCRPC), likely due to the heterogeneous and immune-suppressive microenvironment present in prostate cancer. The identification of molecular biomarkers that could predict response to immunotherapy represents one of the current challenges in this clinical scenario. The management of advanced castration-resistant prostate cancer is rapidly evolving and immunotherapy treatments, mostly consisting of immune checkpoint inhibitors combinations, BiTE ® (bispecific T-cell engager) immune therapies, and chimeric antigen receptors (CAR) are in development with promising results. This review analyses the current evidence of immunotherapy treatments for mCRPC, evaluating past failures and promising approaches and discussing the directions for future research.

Datos de la publicación

ISSN/ISSNe:: 2227-9059, 2227-9059
Tipo:: Article
Páginas:: -
DOI:: 10.3390/biomedicines10030537
PubMed:: 35327339
Factor de Impacto:: 0,874 SCImago ℠
Cuartil:: Q1 SCImago ℠

Documentos

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Métricas

Filiaciones

Lopez-Campos, Fernando:: Radiation Oncology Department, Hospital Universitario Ramón y Cajal, 28024 Madrid, Spain
Gajate, Pablo:: Medical Oncology Department, Hospital Universitario Ramón y Cajal, 28024 Madrid, Spain
Romero-Laorden, Nuria:: Medical Oncology Department, Hospital Universitario La Princesa, 28006 Madrid, Spain
Zafra-Martin, Juan:: Department of Radiation Oncology, Hospital Universitario Virgen de la Victoria, 29010 Malaga, Spain
Juan, Manel:: Servei d'Immunologia, CDB-Hospital Clínic, Plataforma de Inmunoterapia HSJD-Clínic, 08036 Barcelona, Spain
Hernando Polo, Susana:: Medical Oncology Department, Hospital Universitario Fundación Alcorcón, 28922 Alcorcón, Spain
Conde Moreno, Antonio:: Radiation Oncology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain
Couñago F:: Department of Radiation Oncology, Hospital Universitario Quirónsalud, 28223 Madrid, Spain

Department of Radiation Oncology, Hospital La Luz, 28003 Madrid, Spain

Universidad Europea de Madrid, 28670 Madrid, Spain