Nests of dividing neuroblasts sustain interneuron production for the developing human brain.

Fecha de publicación: 28/01/2022 Fecha Ahead of Print: 28/01/2022

Autores de IIS La Fe

Jaime Ferrer Lozano

Autor
Máximo Vento Torres

Autor

Participantes ajenos a IIS La Fe

Paredes, MF
Mora, C
Flores-Ramirez, Q
Cebrian-Silla, A
Del Dosso, A
Larimer, P
Chen, JP
Kang, G
Gonzalez Granero, Susana
Garcia, E
Chu, JL
Delgado, R
Cotter, JA
Tang, V
Spatazza, J
Obernier, K
Scott, J
Studholme, C
Nowakowski, TJ
Kriegstein, AR
Oldham, MC
Hasenstaub, A
Garcia-Verdugo JM
Alvarez-Buylla, A
Huang, EJ

Grupos

Perinatología

Abstract

The human cortex contains inhibitory interneurons derived from the medial ganglionic eminence (MGE), a germinal zone in the embryonic ventral forebrain. How this germinal zone generates sufficient interneurons for the human brain remains unclear. We found that the human MGE (hMGE) contains nests of proliferative neuroblasts with ultrastructural and transcriptomic features that distinguish them from other progenitors in the hMGE. When dissociated hMGE cells are transplanted into the neonatal mouse brain, they reform into nests containing proliferating neuroblasts that generate young neurons that migrate extensively into the mouse forebrain and mature into different subtypes of functional interneurons. Together, these results indicate that the nest organization and sustained proliferation of neuroblasts in the hMGE provide a mechanism for the extended production of interneurons for the human forebrain.

Datos de la publicación

ISSN/ISSNe:: 0036-8075, 1095-9203
Tipo:: Article
Páginas:: 402-402
DOI:: 10.1126/science.abk2346
PubMed:: 35084970
Factor de Impacto:: 14,589 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Filiaciones

Paredes, MF:: Department of Neurology, University of California, San Francisco, CA 94143, USA

Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA

Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA

Developmental and Stem Cell Graduate Program, University of California, San Francisco, CA 94143, USA
Mora, C:: Department of Pathology, University of California, San Francisco, CA 94143, USA
Flores-Ramirez, Q:: Department of Neurology, University of California, San Francisco, CA 94143, USA
Cebrian-Silla, A:: Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA

Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Del Dosso, A:: Department of Pathology, University of California, San Francisco, CA 94143, USA
Larimer, P:: Department of Neurology, University of California, San Francisco, CA 94143, USA
Chen, JP:: Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA

Department of Pathology, University of California, San Francisco, CA 94143, USA
Kang, G:: Developmental and Stem Cell Graduate Program, University of California, San Francisco, CA 94143, USA

Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Gonzalez Granero, Susana:: Laboratorio de Neurobiología Comparada, Instituto Cavanilles de Biodiversidad y Biología Evolutiva, Universitat de València-Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Valencia, Spain
Garcia, E:: Department of Neurology, University of California, San Francisco, CA 94143, USA
Chu, JL:: Department of Neurology, University of California, San Francisco, CA 94143, USA
Delgado, R:: Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA
Cotter, JA:: Department of Pathology, Children's Hospital Los Angeles, and Keck School of Medicine of University of Southern California, Los Angeles, CA 90027, USA
Tang, V:: Department of Pathology, University of California, San Francisco, CA 94143, USA
Spatazza, J:: Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Obernier, K:: Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Ferrer Lozano, Jaime:: Department of Pathology, Hospital Universitari i Politècnic la Fe, Valencia, Spain
Vento, M:: Instituto de Investigación. Neonatal Research Group, Health Research Institute La Fe, Valencia, Spain

Division of Neonatology, University and Polytechnic Hospital La Fe, Valencia, Spain
Scott, J:: Department of Bioengineering, Santa Clara University, Santa Clara, CA 95053, USA
Studholme, C:: Biomedical Image Computing Group, Departments of Pediatrics, Bioengineering, and Radiology, University of Washington, Seattle, WA 98195, USA

Department of Bioengineering, University of Washington, Seattle, WA 98195, USA

Department of Radiology, University of Washington, Seattle, WA 98195, USA
Nowakowski, TJ:: Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA

Department of Anatomy and Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA 94143, USA
Kriegstein, AR:: Department of Neurology, University of California, San Francisco, CA 94143, USA

Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA

Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA

Developmental and Stem Cell Graduate Program, University of California, San Francisco, CA 94143, USA
Oldham, MC:: Developmental and Stem Cell Graduate Program, University of California, San Francisco, CA 94143, USA

Department of Pathology, University of California, San Francisco, CA 94143, USA

Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Hasenstaub, A:: Department of Otolaryngology, University of California, San Francisco, CA 94143, USA
Garcia-Verdugo JM:: Laboratorio de Neurobiología Comparada, Instituto Cavanilles de Biodiversidad y Biología Evolutiva, Universitat de València-Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Valencia, Spain
Alvarez-Buylla, A:: Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA

Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA

Developmental and Stem Cell Graduate Program, University of California, San Francisco, CA 94143, USA

Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Huang, EJ:: Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA

Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA

Developmental and Stem Cell Graduate Program, University of California, San Francisco, CA 94143, USA

Department of Pathology, University of California, San Francisco, CA 94143, USA

Keywords

GANGLIONIC EMINENCE; NEURAL STEM; RADIAL GLIA; MIGRATION; EXPRESSION; GENES; CELLS; SPECIFICATION; ORGANIZATION; PROGENITORS

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