Screening-detected positive serology for celiac disease: a real clinical challenge.

Autores de IIS La Fe

• Ester Donat Aliaga

  Autor

• María Roca Llorens

  Autor

• Etna Masip Simó

  Autor

• Begoña Polo Miquel

  Autor

• David Ramos Escorihuela

  Autor

• 

  Carmen Ribes Koninckx

  Autor

Grupos

• Enfermedad celíaca e Inmunopatología digestiva

Abstract

According to European Society for Paediatric Gastroenterology, Hepatology, and Nutrition 2020 criteria for celiac disease diagnosis, the small bowel biopsy (SBB) can be omitted in selected circumstances, even in asymptomatic patients. Hence, we have conducted a retrospective study to identify the histological findings of the asymptomatic patients with antitransglutaminase IgA antibodies 10 times above the upper limit of normal and positive antiendomisium antibodies; 5/24 patients fulfilling these criteria had, however, a nonconclusive SBB and were diagnosed with potential celiac disease. The nonbiopsy approach in these cases needs to be carefully evaluated and the risk of overdiagnosis pondered as the management and evolution of potential celiac disease cases is still a matter of study.

Keywords

• asymptomatic; celiac disease; nonbiopsy approach; positive serology; screening