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  3. Association between Neutrophil-Lymphocyte ratio, Platelet-Lymphocyte ratio, and C-Reactive Protein levels and metabolic status in patients with a bipolar disorder.

Association between Neutrophil-Lymphocyte ratio, Platelet-Lymphocyte ratio, and C-Reactive Protein levels and metabolic status in patients with a bipolar disorder.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Sanchez-Autet, Monica
  • Arranz, Belen
  • Safont, Gemma
  • de la Fuente, Lorena
  • Garriga, Marina
  • Marin, Lorena
  • García-Portilla MP

Grupos

Abstract

OBJECTIVES: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-Reactive Protein (CRP) are markers of inflammation that are elevated in bipolar disorder (BD) and are also related to a higher risk of metabolic syndrome (MetS). This study aimed at investigating for the first time the association between NLR, PLR, and CRP and the metabolic status in BD. METHODS: We assessed the association between biomarkers and the metabolic status: number of metabolic risk factors, presence of MetS, insulin sensitivity (Quantitative Insulin Sensitivity Check Index, QUICKI) and insulin resistance (Homeostatic Model Assessment for Insulin Resistance, HOMA-IR index), in a sample of 219 outpatients with BD. RESULTS: 25.9% of the sample met the criteria for MetS. High levels of CRP were found in 12% of the sample. Older age, low PLR, high NLR, and high CRP levels significantly predicted a higher number of MetS risk factors (p < 0.001). Older age and low PLR were associated with a greater likelihood of developing MetS (p = 0.007). CONCLUSIONS: Although further studies are needed to replicate and validate these findings, inflammatory biomarkers as CRP, PLR and NLR could be useful tools to identify patients with a BD at risk for a metabolic adverse outcome.

Datos de la publicación

ISSN/ISSNe:
1562-2975, 1814-1412

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY  Taylor & Francis

Tipo:
Article
Páginas:
1-27
PubMed:
34856870
Factor de Impacto:
0,988 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 9

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Keywords

  • Bipolar affective disorder; C-Reactive Protein; Glucose metabolism; Inflammation

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