20 years of leptin: Role of leptin in cardiomyocyte physiology and physiopathology

Autores de IIS La Fe

• Manuel Portoles Sanz

  Autor

• 

  Esther Roselló Lletí

  Autor

• Jose Miguel Rivera Otero

  Autor

• Carlos Gonzalez Juanatey

  Autor

• José Francisco Dolz Lago

  Autor

Participantes ajenos a IIS La Fe

• Feijóo-Bandín S

Grupos

• Grupo de Investigación Clínica y Traslacional en Cardiología

Abstract

Since the discovery of leptin in 1994 by Zhang et al., there have been a number of reports showing its implication in the development of a wide range of cardiovascular diseases. However, there exists some controversy about how leptin can induce or preserve cardiovascular function, as different authors have found contradictory results about leptin beneficial or detrimental effects in leptin deficient/resistant murine models and in wild type tissue and cardiomyocytes. Here, we will focus on the main discoveries about the leptin functions at cardiac level within the last two decades, focusing on its role in cardiac metabolism, remodeling and contractile function. (C) 2015 Elsevier Inc. All rights reserved.

Keywords

• Cardiomyocytes; Leptin; Metabolism; Viability; Contractile function