Global Methylome Scores Correlate with Histological Subtypes of Colorectal Carcinoma and Show Different Associations with Common Clinical and Molecular Features.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Turpín-Sevilla MDC
- Pérez-Sanz F
- García-Solano J
- Trujillo-Santos J
- Carbonell P
- Estrada E
- Tuomisto A
- Herruzo I
- Fennell LJ
- Mäkinen MJ
- Rodríguez-Braun E
- Whitehall VLJ
- Conesa A
- Conesa-Zamora P
Grupos
Abstract
The typical methylation patterns associated with cancer are hypermethylation at gene promoters and global genome hypomethylation. Aberrant CpG island hypermethylation at promoter regions and global genome hypomethylation have not been associated with histological colorectal carcinomas (CRC) subsets. Using Illumina's 450 k Infinium Human Methylation beadchip, the methylome of 82 CRCs were analyzed, comprising different histological subtypes: 40 serrated adenocarcinomas (SAC), 32 conventional carcinomas (CC) and 10 CRCs showing histological and molecular features of microsatellite instability (hmMSI-H), and, additionally, 35 normal adjacent mucosae. Scores reflecting the overall methylation at 250 bp, 1 kb and 2 kb from the transcription starting site (TSS) were studied.
Datos de la publicación
- ISSN/ISSNe:
- 2072-6694, 2072-6694
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 34680315
- Factor de Impacto:
- 1,349 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Cancers MDPI
Citas Recibidas en Web of Science: 3
Documentos
- No hay documentos
Filiaciones
Keywords
- CIMP, DNA methylation, colorectal carcinoma, conventional carcinoma, epigenetics of carcinogenesis, methylation score, methylome, microsatellite instability, serrated adenocarcinoma, serrated pathway
Campos de Estudio
Cita
Turpín MDC,Pérez F,García J,SEBASTIÁN P,Trujillo J,Carbonell P,Estrada E,Tuomisto A,Herruzo I,Fennell LJ,Mäkinen MJ,Rodríguez E,Whitehall VLJ,Conesa A,Conesa P. Global Methylome Scores Correlate with Histological Subtypes of Colorectal Carcinoma and Show Different Associations with Common Clinical and Molecular Features. Cancers. 2021. 13. (20):5165. IF:6,575. (1).
Portal de investigación