Global Methylome Scores Correlate with Histological Subtypes of Colorectal Carcinoma and Show Different Associations with Common Clinical and Molecular Features.

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Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Turpín-Sevilla MDC
  • Pérez-Sanz F
  • García-Solano J
  • Trujillo-Santos J
  • Carbonell P
  • Estrada E
  • Tuomisto A
  • Herruzo I
  • Fennell LJ
  • Mäkinen MJ
  • Rodríguez-Braun E
  • Whitehall VLJ
  • Conesa A
  • Conesa-Zamora P

Grupos

Abstract

The typical methylation patterns associated with cancer are hypermethylation at gene promoters and global genome hypomethylation. Aberrant CpG island hypermethylation at promoter regions and global genome hypomethylation have not been associated with histological colorectal carcinomas (CRC) subsets. Using Illumina's 450 k Infinium Human Methylation beadchip, the methylome of 82 CRCs were analyzed, comprising different histological subtypes: 40 serrated adenocarcinomas (SAC), 32 conventional carcinomas (CC) and 10 CRCs showing histological and molecular features of microsatellite instability (hmMSI-H), and, additionally, 35 normal adjacent mucosae. Scores reflecting the overall methylation at 250 bp, 1 kb and 2 kb from the transcription starting site (TSS) were studied.

Datos de la publicación

ISSN/ISSNe:
2072-6694, 2072-6694

Cancers  MDPI

Tipo:
Article
Páginas:
-
PubMed:
34680315
Factor de Impacto:
1,349 SCImago
Cuartil:
Q1 SCImago

Citas Recibidas en Web of Science: 3

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Keywords

  • CIMP, DNA methylation, colorectal carcinoma, conventional carcinoma, epigenetics of carcinogenesis, methylation score, methylome, microsatellite instability, serrated adenocarcinoma, serrated pathway

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