The impact of GVHD on outcomes after adult single cord blood transplantation in European and Japanese populations.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Kanda, Junya
- Hayashi, Hiromi
- Ruggeri, Annalisa
- Kimura, Fumihiko
- Volt, Fernanda
- Takahashi, Satoshi
- Kako, Shinichi
- Tozatto-Maio, Karina
- Yanada, Masamitsu
- Uchida, Naoyuki
- Angelucci, Emanuele
- Kato, Seiko
- Mohty, Mohamad
- Forcade, Edouard
- Tanaka, Masatsugu
- Sierra, Jorge
- Ohta, Takanori
- Saccardi, Riccardo
- Fukuda, Takahiro
- Ichinohe, Tatsuo
- Kimura, Takafumi
- Rocha, Vanderson
- Okamoto, Shinichiro
- Nagler, Arnon
- Atsuta, Yoshiko
- Gluckman, Eliane
Grupos
Abstract
The impact of GVHD and graft-versus-leukemia effect in unrelated cord blood transplantation (UCBT) is controversial. In the Eurocord/ALWP EBMT and JSTCT/JDCHCT collaborative study, we evaluated the impact of GVHD on UCBT outcomes in Japanese and European registries. A total of 3,690 adult patients with acute leukemia who received their first single UCBT were included. A multivariate analysis of overall survival (OS) revealed a positive impact of grade II acute GVHD compared with grade 0-I GVHD, in the Japanese cohort (hazard ratio (HR), 0.81; P = 0.001), and an adverse impact in the European cohort (HR, 1.37; P = 0.007). A negative impact of grade III-IV acute GVHD on OS was observed regardless of registries. In the analysis of relapse, a positive impact of grade II acutes GVHD compared with grade 0-I GVHD was observed only in the Japanese cohort, regardless of disease risk. The positive impact of limited chronic GVHD on OS was observed only in the Japanese cohort. In conclusion, a positive impact of mild GVHD after a single UCBT was observed only in the Japanese cohort. This could explain the ethnic difference in UCBT outcomes and might contribute to the preference usage of UCBT in Japan.
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
Datos de la publicación
- ISSN/ISSNe:
- 0268-3369, 1476-5365
- Tipo:
- Article
- Páginas:
- 57-64
- PubMed:
- 34635798
- Factor de Impacto:
- 0,998 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
BONE MARROW TRANSPLANTATION NATURE PUBLISHING GROUP
Citas Recibidas en Web of Science: 9
Documentos
- No hay documentos
Filiaciones
Keywords
- VERSUS-HOST-DISEASE; STEM-CELL TRANSPLANTATION; SIBLING BONE-MARROW; UNRELATED DONOR; RISK-FACTORS; ACUTE-LEUKEMIA; GRAFT; HLA; SURVIVAL; MORTALITY
Cita
Kanda J,Hayashi H,Ruggeri A,Kimura F,Volt F,Takahashi S,Kako S,Tozatto K,Yanada M,SANZ G,Uchida N,Angelucci E,Kato S,Mohty M,Forcade E,Tanaka M,Sierra J,Ohta T,Saccardi R,Fukuda T,Ichinohe T,Kimura T,Rocha V,Okamoto S,Nagler A,Atsuta Y,Gluckman E. The impact of GVHD on outcomes after adult single cord blood transplantation in European and Japanese populations. Bone Marrow Transplant. 2022. 57. (1):p. 57-64. IF:4,800. (1).
Portal de investigación