The impact of GVHD on outcomes after adult single cord blood transplantation in European and Japanese populations.

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Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Kanda, Junya
  • Hayashi, Hiromi
  • Ruggeri, Annalisa
  • Kimura, Fumihiko
  • Volt, Fernanda
  • Takahashi, Satoshi
  • Kako, Shinichi
  • Tozatto-Maio, Karina
  • Yanada, Masamitsu
  • Uchida, Naoyuki
  • Angelucci, Emanuele
  • Kato, Seiko
  • Mohty, Mohamad
  • Forcade, Edouard
  • Tanaka, Masatsugu
  • Sierra, Jorge
  • Ohta, Takanori
  • Saccardi, Riccardo
  • Fukuda, Takahiro
  • Ichinohe, Tatsuo
  • Kimura, Takafumi
  • Rocha, Vanderson
  • Okamoto, Shinichiro
  • Nagler, Arnon
  • Atsuta, Yoshiko
  • Gluckman, Eliane

Grupos

Abstract

The impact of GVHD and graft-versus-leukemia effect in unrelated cord blood transplantation (UCBT) is controversial. In the Eurocord/ALWP EBMT and JSTCT/JDCHCT collaborative study, we evaluated the impact of GVHD on UCBT outcomes in Japanese and European registries. A total of 3,690 adult patients with acute leukemia who received their first single UCBT were included. A multivariate analysis of overall survival (OS) revealed a positive impact of grade II acute GVHD compared with grade 0-I GVHD, in the Japanese cohort (hazard ratio (HR), 0.81; P = 0.001), and an adverse impact in the European cohort (HR, 1.37; P = 0.007). A negative impact of grade III-IV acute GVHD on OS was observed regardless of registries. In the analysis of relapse, a positive impact of grade II acutes GVHD compared with grade 0-I GVHD was observed only in the Japanese cohort, regardless of disease risk. The positive impact of limited chronic GVHD on OS was observed only in the Japanese cohort. In conclusion, a positive impact of mild GVHD after a single UCBT was observed only in the Japanese cohort. This could explain the ethnic difference in UCBT outcomes and might contribute to the preference usage of UCBT in Japan.

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

Datos de la publicación

ISSN/ISSNe:
0268-3369, 1476-5365

BONE MARROW TRANSPLANTATION  NATURE PUBLISHING GROUP

Tipo:
Article
Páginas:
57-64
PubMed:
34635798
Factor de Impacto:
0,998 SCImago
Cuartil:
Q2 SCImago

Citas Recibidas en Web of Science: 9

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Keywords

  • VERSUS-HOST-DISEASE; STEM-CELL TRANSPLANTATION; SIBLING BONE-MARROW; UNRELATED DONOR; RISK-FACTORS; ACUTE-LEUKEMIA; GRAFT; HLA; SURVIVAL; MORTALITY

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