A Standardised Approach to the Biomechanical Evaluation of Tracheal Grafts.

Fecha de publicación: 05/10/2021 Fecha Ahead of Print: 05/10/2021

Autores de IIS La Fe

José Cerón Navarro

Autor

Participantes ajenos a IIS La Fe

Martinez-Hernandez, Nestor J.
Mas-Estelles, Jorge
Milian-Medina, Lara
Martinez-Ramos, Cristina
Galbis-Caravajal, Jose
Roig-Bataller, Amparo
Mata-Roig, Manuel

Grupos

Unidad de Biomarcadores y Medicina de Precisión (UBYMP)

Abstract

The ideal tracheal substitute must have biomechanical properties comparable to the native trachea, but currently there is no standardised approach to evaluating these properties. Here we propose a novel method for evaluating and comparing the properties of tracheal substitutes, thus systematising both measurement and data curation. This system was tested by comparing native rabbit tracheas to frozen and decellularised specimens and determining the histological characteristics of those specimens. We performed radial compression tests on the anteroposterior tracheal axis and longitudinal axial tensile tests with the specimens anastomosed to the jaw connected to a measuring system. All calculations and results were adjusted according to tracheal size, always using variables relative to the tracheal dimensions, thus permitting comparison of different sized organs. The biomechanical properties of the decellularised specimens were only slightly reduced compared to controls and significant in regard to the maximum stress withstood in the longitudinal axis (-0.246 MPa CI [-0.248, -0.145] MPa) and the energy stored per volume unit (-0.124 mJ·mm -3 CI [-0.195, -0.055] mJ·mm -3 ). The proposed method is suitable for the systematic characterisation of the biomechanical properties of different tracheal substitutes, regardless of the size or nature of the substitute, thus allowing for direct comparisons.

Datos de la publicación

ISSN/ISSNe:: 2218-273X, 2218-273X
Tipo:: Article
Páginas:: -
DOI:: 10.3390/biom11101461
PubMed:: 34680094
Factor de Impacto:: 1,019 SCImago ℠
Cuartil:: Q2 SCImago ℠

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Métricas

Filiaciones

Martinez-Hernandez, Nestor J.:: Thoracic Surgery Department, Hospital Universitari de la Ribera, 46600 Valencia, Spain

Hosp Univ de la Ribera, Dept Thorac Surg, Valencia 46600, Spain
Mas-Estelles, Jorge:: Biomaterials Center, Universitat Politècnica de València, 46022 Valencia, Spain

Univ Politecn Valencia, Biomat Ctr, Valencia 46022, Spain
Milian-Medina, Lara:: Pathology Department, Medicine and Odontology Faculty, Universitat de València, 46010 Valencia, Spain

Univ Valencia, Fac Med & Odontol, Dept Pathol, Valencia 46010, Spain
Martinez-Ramos, Cristina:: Biomaterials Center, Universitat Politècnica de València, 46022 Valencia, Spain

Univ Politecn Valencia, Biomat Ctr, Valencia 46022, Spain
Ceron-Navarro, Jose:: Thoracic Surgery Department, Hospital Universitari i Politècnic la Fe, 46026 Valencia, Spain

Hosp Univ & Politecn la Fe, Dept Thorac Surg, Valencia 46026, Spain
Galbis-Caravajal, Jose:: Thoracic Surgery Department, Hospital Universitari de la Ribera, 46600 Valencia, Spain

Hosp Univ de la Ribera, Dept Thorac Surg, Valencia 46600, Spain
Roig-Bataller, Amparo:: Thoracic Surgery Department, Hospital Universitari de la Ribera, 46600 Valencia, Spain

Hosp Univ de la Ribera, Dept Thorac Surg, Valencia 46600, Spain
Mata-Roig, Manuel:: Pathology Department, Medicine and Odontology Faculty, Universitat de València, 46010 Valencia, Spain

Networking Research Center on Respiratory Diseases (CIBERER), ISCIII, 28029 Madrid, Spain

Univ Valencia, Fac Med & Odontol, Dept Pathol, Valencia 46010, Spain

ISCIII, Networking Res Ctr Resp Dis CIBERER, Madrid 28029, Spain

Keywords

airway, bioengineering, biomechanics, tissue engineering, trachea, transplantation