Results of a randomized phase 3 study of oral sapacitabine in elderly patients with newly diagnosed acute myeloid leukemia (SEAMLESS)
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Kantarjian, Hagop M.
- Begna, Kebede H.
- Altman, Jessica K.
- Goldberg, Stuart L.
- Sekeres, Mikkael A.
- Strickland, Stephen A.
- Arellano, Martha L.
- Claxton, David F.
- Baer, Maria R.
- Gautier, Marc
- Berman, Ellin
- Seiter, Karen
- Solomon, Scott R.
- Schiller, Gary J.
- Luger, Selina M.
- Butrym, Aleksandra
- Gaidano, Gianluca
- Thomas, Xavier G.
- Rizzieri, David A.
- Quick, Donald P.
- Venugopal, Parameswaran
- Gaur, Rakesh
- Maness, Lori J.
- Kadia, Tapan M.
- Ravandi, Farhad
- Buyse, Marc E.
- Chiao, Judy H.
Grupos
Abstract
Acute myeloid leukemia (AML) is fatal in elderly patients who are unfit for standard induction chemotherapy. The objective of this study was to evaluate the survival benefit of administering sapacitabine, an oral nucleoside analogue, in alternating cycles with decitabine, a low-intensity therapy, to elderly patients with newly diagnosed AML.
Datos de la publicación
- ISSN/ISSNe:
- 0008-543X, 1097-0142
- Tipo:
- Article
- Páginas:
- 4421-4431
- DOI:
- 10.1002/cncr.33828
- PubMed:
- 34424530
- Factor de Impacto:
- 2,463 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
CANCER WILEY-BLACKWELL
Citas Recibidas en Web of Science: 4
Documentos
- No hay documentos
Filiaciones
Keywords
- acute myeloid leukemia (AML), decitabine, hypomethylation, sapacitabine, therapy
Campos de Estudio
Cita
Kantarjian HM,Begna KH,Altman JK,Goldberg SL,Sekeres MA,Strickland SA,Arellano ML,Claxton DF,Baer MR,Gautier M,Berman E,Seiter K,Solomon SR,Schiller GJ,Luger SM,Butrym A,Gaidano G,Thomas XG,MONTESINOS P,Rizzieri DA,Quick DP,Venugopal P,Gaur R,Maness LJ,Kadia TM,Ravandi F,Buyse ME,Chiao JH. Results of a randomized phase 3 study of oral sapacitabine in elderly patients with newly diagnosed acute myeloid leukemia (SEAMLESS). Cancer. 2021. 127. (23):p. 4421-4431. IF:6,921. (1).
Portal de investigación