Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.

Fecha de publicación: 07/06/2021 Fecha Ahead of Print: 07/06/2021

Autores de IIS La Fe

Jordi Perez Tur

Autor

Participantes ajenos a IIS La Fe

de Rojas, Itziar
Moreno-Grau, Sonia
Tesi, Niccolo
Grenier-Boley, Benjamin
Andrade, Victor
Jansen, Iris E
Pedersen, Nancy L
Stringa, Najada
Zettergren, Anna
Hernandez, Isabel
Montrreal, Laura
Antunez, Carmen
Antonell, Anna
Tankard, Rick M
Bis, Joshua C
Sims, Rebecca
Bellenguez, Celine
Quintela, Ines
Gonzalez-Perez, Antonio
Calero, Miguel
Franco-Macias, Emilio
Macias, Juan
Blesa, Rafael
Cervera-Carles, Laura
Menendez-Gonzalez, Manuel
Frank-Garcia, Ana
Royo, Jose Luis
Moreno, Fermin
Huerto Vilas, Raquel
Baquero, Miquel
Diez-Fairen, Monica
Lage, Carmen
Garcia-Madrona, Sebastian
Garcia-Gonzalez, Pablo
Alarcon-Martin, Emilio
Valero, Sergi
Sotolongo-Grau, Oscar
Ullgren, Abbe
Naj, Adam C
Lemstra, Afina W
Benaque, Alba
Perez-Cordon, Alba
Benussi, Alberto
Rabano, Alberto
Padovani, Alessandro
Squassina, Alessio
de Mendonca, Alexandre
Arias Pastor, Alfonso
Kok, Almar A L
Meggy, Alun
Pastor, Ana Belen
Espinosa, Ana
Corma-Gomez, Anais
Martin Montes, Angel
Sanabria, Angela
DeStefano, Anita L
Schneider, Anja
Haapasalo, Annakaisa
Kinhult Stahlbom, Anne
Tybjarg-Hansen, Anne
Hartmann, Annette M
Spottke, Annika
Corbaton-Anchuelo, Arturo
Rongve, Arvid
Borroni, Barbara
Arosio, Beatrice
Nacmias, Benedetta
Nordestgaard, Borge G
Kunkle, Brian W
Charbonnier, Camille
Abdelnour, Carla
Masullo, Carlo
Martinez Rodriguez, Carmen
Munoz-Fernandez, Carmen
Dufouil, Carole
Graff, Caroline
Ferreira, Catarina B
Chillotti, Caterina
Reynolds, Chandra A
Fenoglio, Chiara
Van Broeckhoven, Christine
Clark, Christopher
Pisanu, Claudia
Satizabal, Claudia L
Holmes, Clive
Buiza-Rueda, Dolores
Aarsland, Dag
Rujescu, Dan
Alcolea, Daniel
Galimberti, Daniela
Wallon, David
Seripa, Davide
Grunblatt, Edna
Dardiotis, Efthimios
Duzel, Emrah
Scarpini, Elio
Conti, Elisa
Rubino, Elisa
Gelpi, Ellen
Rodriguez-Rodriguez, Eloy
Duron, Emmanuelle
Boerwinkle, Eric
Ferri, Evelyn
Tagliavini, Fabrizio
Kucukali, Fahri
Pasquier, Florence
Sanchez-Garcia, Florentino
Mangialasche, Francesca
Jessen, Frank
Nicolas, Gael
Selbak, Geir
Ortega, Gemma
Chene, Genevieve
Hadjigeorgiou, Georgios
Rossi, Giacomina
Spalletta, Gianfranco
Giaccone, Giorgio
Grande, Giulia
Binetti, Giuliano
Papenberg, Goran
Hampel, Harald
Bailly, Henri
Zetterberg, Henrik
Soininen, Hilkka
Karlsson, Ida K
Alvarez, Ignacio
Appollonio, Ildebrando
Giegling, Ina
Skoog, Ingmar
Saltvedt, Ingvild
Rainero, Innocenzo
Rosas Allende, Irene
Hort, Jakub
Diehl-Schmid, Janine
Van Dongen, Jasper
Vidal, Jean-Sebastien
Lehtisalo, Jenni
Wiltfang, Jens
Thomassen, Jesper Qvist
Kornhuber, Johannes
Haines, Jonathan L
Vogelgsang, Jonathan
Pineda, Juan A
Fortea, Juan
Popp, Julius
Deckert, Jurgen
Buerger, Katharina
Morgan, Kevin
FlieSSbach, Klaus
Sleegers, Kristel
Molina-Porcel, Laura
Kilander, Lena
Weinhold, Leonie
Farrer, Lindsay A
Wang, Li-San
Kleineidam, Luca
Farotti, Lucia
Parnetti, Lucilla
Tremolizzo, Lucio
Hausner, Lucrezia
Benussi, Luisa
Froelich, Lutz
Ikram, M Arfan
Deniz-Naranjo, M Candida
Tsolaki, Magda
Rosende-Roca, Maitee
Lowenmark, Malin
Hulsman, Marc
Spallazzi, Marco
Pericak-Vance, Margaret A
Esiri, Margaret
Bernal Sanchez-Arjona, Maria
Dalmasso, Maria Carolina
Martinez-Larrad, Maria Teresa
Arcaro, Marina
Nothen, Markus M
Fernandez-Fuertes, Marta
Dichgans, Martin
Ingelsson, Martin
Herrmann, Martin J
Scherer, Martin
Vyhnalek, Martin
Kosmidis, Mary H
Yannakoulia, Mary
Schmid, Matthias
Ewers, Michael
Heneka, Michael T
Wagner, Michael
Scamosci, Michela
Kivipelto, Miia
Hiltunen, Mikko
Zulaica, Miren
Alegret, Montserrat
Fornage, Myriam
Roberto, Natalia
van Schoor, Natasja M
Seidu, Nazib M
Banaj, Nerisa
Armstrong, Nicola J
Scarmeas, Nikolaos
Scherbaum, Norbert
Goldhardt, Oliver
Hanon, Oliver
Peters, Oliver
Skrobot, Olivia Anna
Quenez, Olivier
Lerch, Ondrej
Bosso, Paola
Caffarra, Paolo
Dionigi Rossi, Paolo
Sakka, Paraskevi
Hoffmann, Per
Holmans, Peter A
Fischer, Peter
Riederer, Peter
Yang, Qiong
Marshall, Rachel
Kalaria, Rajesh N
Mayeux, Richard
Vandenberghe, Rik
Cecchetti, Roberta
Ghidoni, Roberta
Frikke-Schmidt, Ruth
Sorbi, Sandro
Hagg, Sara
Engelborghs, Sebastiaan
Helisalmi, Seppo
Botne Sando, Sigrid
Kern, Silke
Archetti, Silvana
Boschi, Silvia
Fostinelli, Silvia
Gil, Silvia
Mendoza, Silvia
Mead, Simon
Ciccone, Simona
Djurovic, Srdjan
Heilmann-Heimbach, Stefanie
Riedel-Heller, Steffi
Kuulasmaa, Teemu
Del Ser, Teodoro
Lebouvier, Thibaud
Polak, Thomas
Ngandu, Tiia
Grimmer, Timo
Bessi, Valentina
Escott-Price, Valentina
Giedraitis, Vilmantas
Deramecourt, Vincent
Maier, Wolfgang
Jian, Xueqiu
Pijnenburg, Yolande A L
Kehoe, Patrick Gavin
Garcia-Ribas, Guillermo
Sanchez-Juan, Pascual
Pastor, Pau
Pinol-Ripoll, Gerard
Lopez de Munain, Adolfo
Garcia-Alberca, Jose Maria
Bullido, Maria J
Alvarez, Victoria
Lleo, Alberto
Real, Luis M
Mir, Pablo
Medina, Miguel
Scheltens, Philip
Holstege, Henne
Marquie, Marta
Saez, Maria Eugenia
Carracedo, Angel
Amouyel, Philippe
Schellenberg, Gerard D
Williams, Julie
Seshadri, Sudha
van Duijn, Cornelia M
Mather, Karen A
Sanchez-Valle, Raquel
Serrano-Rios, Manuel
Orellana, Adelina
Tarraga, Lluis
Blennow, Kaj
Huisman, Martijn
Andreassen, Ole A
Posthuma, Danielle
Clarimon, Jordi
Boada, Merce
van der Flier, Wiesje M
Ramirez, Alfredo
Lambert, Jean-Charles
van der Lee, Sven J
Ruiz, Agustin
EADB contributors
GR@ACE study group
DEGESCO consortium
IGAP (ADGC, CHARGE, EADI, GERAD)
PGC-ALZ consortia

Abstract

Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ?4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease.

Datos de la publicación

ISSN/ISSNe:: 2041-1723, 2041-1723
Tipo:: Article
Páginas:: 3417-3417
DOI:: 10.1038/s41467-021-22491-8
Factor de Impacto:: 4,846 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Métricas

Filiaciones

de Rojas, Itziar:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Moreno-Grau, Sonia:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Tesi, Niccolo:: 4 Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

5 Vrije Univ Amsterdam, Sect Genom Neurodegenerat Dis & Aging, Dept Clin Genet, Amsterdam UMC, Amsterdam, Netherlands

6 Delft Univ Technol, Delft Bioinformat Lab, Delft, Netherlands
Grenier-Boley, Benjamin:: 7 Univ Lille, Inst Pasteur Lille, INSERM, CHU Lille,U1167 Labex DISTALZ RID AGE Risk Factor, Lille, France
Andrade, Victor:: 8 Univ Cologne, Fac Med, Div Neurogenet & Mol Psychiat, Dept Psychiat & Psychotherapy, Cologne, Germany

9 Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Jansen, Iris E:: 10 Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Complex Trait Genet, Amsterdam Neurosci, Amsterdam, Netherlands

4 Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Pedersen, Nancy L:: 11 Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
Stringa, Najada:: 12 Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Data Sci, Amsterdam, Netherlands
Zettergren, Anna:: 13 Univ Gothenburg, Ctr Ageing & Hlth AgeCap, Neuropsychiat Epidemiol Unit,Sahlgrenska Acad, Dept Psychiat & Neurochem,Inst Neurosci & Physiol, Gothenburg, Sweden
Hernandez, Isabel:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Montrreal, Laura:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Antunez, Carmen:: 14 Hosp Clin Univ Virgen Arrixaca, Unidad Demencias, Murcia, Spain
Antonell, Anna:: 15 Univ Barcelona, Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Serv Neurol,Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
Tankard, Rick M:: 16 Murdoch Univ, Math & Stat, Perth, WA, Australia
Bis, Joshua C:: 17 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Sims, Rebecca:: 18 Cardiff Univ, Div Psychol Med & Clinial Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Bellenguez, Celine:: 7 Univ Lille, Inst Pasteur Lille, INSERM, CHU Lille,U1167 Labex DISTALZ RID AGE Risk Factor, Lille, France
Quintela, Ines:: 19 Univ Santiago de Compostela, Grp Med Xenom, Ctr Nacl Genotipado CEGEN PRB3 ISCIII, Santiago De Compostela, Spain
Gonzalez-Perez, Antonio:: 2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Calero, Miguel:: 21 Inst Salud Carlos III, UFIEC, Madrid, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Franco-Macias, Emilio:: 23 Univ Seville, CSIC, Inst Biomed Sevilla IBiS, Unidad Demencias,Serv Neurol & Neurofisiol,Hosp U, Seville, Spain
Macias, Juan:: 24 Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Blesa, Rafael:: 25 Univ Autonoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Cervera-Carles, Laura:: 25 Univ Autonoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Menendez-Gonzalez, Manuel:: 26 Hosp Univ Cent Asturias, Serv Neurol, Oviedo, Spain

27 Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain

28 Univ Oviedo, Dept Med, Oviedo, Spain
Frank-Garcia, Ana:: 29 La Paz Univ Hosp, Dept Neurol, Inst Invest Sanitaria Hosp Univ La Paz, IdiPAZ, Madrid, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

30 Hosp La Paz Inst Hlth Res, IdiPAZ, Madrid, Spain

31 Univ Autonoma Madrid, Madrid, Spain
Royo, Jose Luis:: 32 Univ Malaga, Dept Especialidades Quirurg Bioquim & Inmunol, Sch Med, Malaga, Spain
Moreno, Fermin:: 3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

33 Hosp Univ Donostia, Dept Neurol, San Sebastian, Spain

34 Inst Biodonostia, Neurosci Area, San Sebastian, Spain
Huerto Vilas, Raquel:: 35 Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain

36 Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain
Baquero, Miquel:: 37 Hosp Univ & Politecn La Fe, Serv Neurol, Valencia, Spain
Diez-Fairen, Monica:: 38 Fundacio Docencia & Recerca MutuaTerrassa, Barcelona, Spain

39 Hosp Univ Mutua Terrassa, Memory Disorders Unit, Dept Neurol, Barcelona, Spain
Lage, Carmen:: 3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

40 Univ Cantabria, Univ Hosp, Neurol Serv, Marques de Valdecilla Univ Hosp, Santander, Spain

41 IDIVAL, Santander, Spain
Garcia-Madrona, Sebastian:: 42 Hosp Univ Ramon y Cajal, IRYCIS, Madrid, Spain
Garcia-Gonzalez, Pablo:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Alarcon-Martin, Emilio:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

32 Univ Malaga, Dept Especialidades Quirurg Bioquim & Inmunol, Sch Med, Malaga, Spain
Valero, Sergi:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Sotolongo-Grau, Oscar:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Ullgren, Abbe:: 43 Karolinska Inst, Ctr Alzheimer Res, Dept NVS, Div Neurogeriatr, Stockholm, Sweden

44 Karolinska Univ Hosp Solna, Unit Hereditary Dementias, Stockholm, Sweden
Naj, Adam C:: 45 Univ Penn, Dept Biostat Epidemiol & Informat, Perelman Sch Med, Philadelphia, PA 19104 USA

46 Univ Penn, Dept Pathol & Lab Med, Penn Neurodegenerat Genom Ctr, Perelman Sch Med, Philadelphia, PA USA
Lemstra, Afina W:: 4 Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Benaque, Alba:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Perez-Cordon, Alba:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Benussi, Alberto:: 47 Univ Brescia, Dept Clin & Expt Sci, Ctr Neurodegenerat Disorders, Brescia, Italy
Rabano, Alberto:: 22 Queen Sofia Fdn Alzheimer Ctr, CIEN Fdn, Madrid, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

48 BT CIEN, Madrid, Spain
Padovani, Alessandro:: 47 Univ Brescia, Dept Clin & Expt Sci, Ctr Neurodegenerat Disorders, Brescia, Italy
Squassina, Alessio:: 49 Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, Cagliari, Italy
de Mendonca, Alexandre:: 50 Univ Lisbon, Fac Med, Lisbon, Portugal
Arias Pastor, Alfonso:: 35 Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain

36 Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain
Kok, Almar A L:: 12 Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Data Sci, Amsterdam, Netherlands

51 Vrije Univ Amsterdam, Amsterdam UMC, Dept Psychiat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
Meggy, Alun:: 52 Cardiff Univ, UK Dementia Res Inst Cardiff, Cardiff, Wales
Pastor, Ana Belen:: 22 Queen Sofia Fdn Alzheimer Ctr, CIEN Fdn, Madrid, Spain

48 BT CIEN, Madrid, Spain
Espinosa, Ana:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Corma-Gomez, Anais:: 24 Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Martin Montes, Angel:: 3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

30 Hosp La Paz Inst Hlth Res, IdiPAZ, Madrid, Spain

53 La Paz Univ Hosp, Dept Neurol, La Paz, Spain
Sanabria, Angela:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
DeStefano, Anita L:: 54 Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

55 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
Schneider, Anja:: 56 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

9 Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Haapasalo, Annakaisa:: 57 Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, Finland
Kinhult Stahlbom, Anne:: 43 Karolinska Inst, Ctr Alzheimer Res, Dept NVS, Div Neurogeriatr, Stockholm, Sweden

44 Karolinska Univ Hosp Solna, Unit Hereditary Dementias, Stockholm, Sweden
Tybjarg-Hansen, Anne:: 58 Rigshosp, Dept Clin Biochem, Copenhagen, Denmark

59 Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark
Hartmann, Annette M:: 60 Martin Luther Univ Halle Wittenberg, Univ Clin & Outpatient Clin Psychiat Psychotherap, Halle, Saale, Germany
Spottke, Annika:: 56 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

61 Univ Bonn, Dept Neurol, Bonn, Germany
Corbaton-Anchuelo, Arturo:: 62 Hosp Clin San Carlos IdISSC, Inst Invest Sanitaria, Madrid, Spain

63 Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid, Spain
Rongve, Arvid:: 64 Haugesund Hosp, Helse Fonna, Dept Res & Innovat, Haugesund, Norway

65 Univ Bergen, Inst Clin Med K1, Bergen, Norway
Borroni, Barbara:: 47 Univ Brescia, Dept Clin & Expt Sci, Ctr Neurodegenerat Disorders, Brescia, Italy
Arosio, Beatrice:: 66 Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

67 IRCCS Osped Maggiore Policlin, Fdn Ca Granda, Geriatr Unit, Milan, Italy
Nacmias, Benedetta:: 68 Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy

69 IRCCS Fdn Don Carlo Gnocchi, Florence, Italy
Nordestgaard, Borge G:: 59 Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark

70 Herlev Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark
Kunkle, Brian W:: 71 Univ Miami, Miller Sch Med, Dr John T Macdonald Fdn Dept Human Genet, Miami, FL 33136 USA

72 Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA
Charbonnier, Camille:: 73 Normandie Univ, UNIROUEN, INSERM, CHU Rouen,Dept Genet,U1245, F-76000 Rouen, France

74 CNR MAJ, FHU G4 Genom, F-76000 Rouen, France
Abdelnour, Carla:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Masullo, Carlo:: 75 Univ Cattolica Sacro Cuore, Sch Med, Inst Neurol, Milan, Italy
Martinez Rodriguez, Carmen:: 27 Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain

76 Hosp Cabuenes, Gijon, Spain
Munoz-Fernandez, Carmen:: 77 Hosp Univ Gran Canaria Dr Negrin, Serv Neurol, Las Palmas Gran Canaria, Spain
Dufouil, Carole:: 78 Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, UMR 1219,ISPED,CIC 1401 EC, Bordeaux, France

79 CHU Bordeaux, Pole Sante Publ, Bordeaux, France
Graff, Caroline:: 43 Karolinska Inst, Ctr Alzheimer Res, Dept NVS, Div Neurogeriatr, Stockholm, Sweden

44 Karolinska Univ Hosp Solna, Unit Hereditary Dementias, Stockholm, Sweden
Ferreira, Catarina B:: 80 Univ Lisbon, Inst Med Mol Joao Lobo Antunes, Fac Med, Lisbon, Portugal
Chillotti, Caterina:: 81 Univ Hosp Cagliari, Unit Clin Pharmacol, Cagliari, Italy
Reynolds, Chandra A:: 82 Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA
Fenoglio, Chiara:: 83 Univ Milan, Dino Ferrari Ctr, Milan, Italy
Van Broeckhoven, Christine:: 84 VIB Ctr Mol Neurol, Antwerp, Belgium

85 Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium

86 Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Clark, Christopher:: 87 Univ Zurich, Inst Regenerat Med, Zurich, Switzerland
Pisanu, Claudia:: 49 Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, Cagliari, Italy
Satizabal, Claudia L:: 54 Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

88 Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA

89 UT Hlth San Antonio, Dept Populat Hlth Sci, San Antonio, TX USA
Holmes, Clive:: 90 Univ Southampton, Sch Med, Div Clin Neurosci, Southampton, Hants, England
Buiza-Rueda, Dolores:: 3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

91 Univ Seville, CSIC, Inst Biomed Sevilla IBiS,Hosp Univ Virgen del Roc, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Aarsland, Dag:: 92 Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Old Age Psychiat, London, England

93 Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway
Rujescu, Dan:: 60 Martin Luther Univ Halle Wittenberg, Univ Clin & Outpatient Clin Psychiat Psychotherap, Halle, Saale, Germany
Alcolea, Daniel:: 25 Univ Autonoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Galimberti, Daniela:: 83 Univ Milan, Dino Ferrari Ctr, Milan, Italy

94 Fdn IRCCS Ca Granda Osped Policlin, Milan, Italy
Wallon, David:: 95 Normandie Univ, UNIROUEN, INSERM, CHU Rouen,Dept Neurol,U1245, Rouen, France
Seripa, Davide:: 96 Fdn IRCCS Casa Sollievo Sofferenza, Complex Struct Geriatr, Dept Med Sci, San Giovanni Rotondo, FG, Italy
Grunblatt, Edna:: 100 Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland

97 Univ Zurich, Psychiat Univ Hosp Zurich PUK, Dept Child & Adolescent Psychiat & Psychothera, Zurich, Switzerland

98 Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland

99 Swiss Fed Inst Technol, Zurich, Switzerland
Dardiotis, Efthimios:: 101 Univ Thessaly, Sch Med, Larisa, Greece
Duzel, Emrah:: 102 German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

103 Otto von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany
Scarpini, Elio:: 83 Univ Milan, Dino Ferrari Ctr, Milan, Italy

94 Fdn IRCCS Ca Granda Osped Policlin, Milan, Italy
Conti, Elisa:: 104 Univ Milano Bicocca, Sch Med & Surg, Milan, Italy

105 Milan Ctr Neurosci, Milan, Italy
Rubino, Elisa:: 106 AOU Citta Salute & Sci Torino, Dept Neurosci & Mental Hlth, Turin, Italy
Gelpi, Ellen:: 107 Hosp Clin Barcelona, IDIBAPS, Neurol Tissue Bank Biobanc, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain

108 Med Univ Vienna, Div Neuropathol & Neurochem, Dept Neurol, Vienna, Austria
Rodriguez-Rodriguez, Eloy:: 3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

40 Univ Cantabria, Univ Hosp, Neurol Serv, Marques de Valdecilla Univ Hosp, Santander, Spain

41 IDIVAL, Santander, Spain
Duron, Emmanuelle:: 109 Hop Brousse, APHP, Equipe INSERM 1178, MOODS, Villejuif, France

110 Univ Paris Saclay, UVSQ, INSERM, CESP,Team MOODS, Le Kremlin Bicetre, France

111 Hop Broca, APHP, Paris, France
Boerwinkle, Eric:: 112 Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA

113 Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA
Ferri, Evelyn:: 67 IRCCS Osped Maggiore Policlin, Fdn Ca Granda, Geriatr Unit, Milan, Italy
Tagliavini, Fabrizio:: 114 Fdn IRCCS Ist Neurol Carlo Besta, Milan, Italy
Kucukali, Fahri:: 84 VIB Ctr Mol Neurol, Antwerp, Belgium

85 Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium

86 Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Pasquier, Florence:: 115 Univ Lille, LiCEND, INSERM, CHU,DISTAlz,U1172, Lille, France

116 CHU CNR MAJ, Lille, France
Sanchez-Garcia, Florentino:: 117 Hosp Univ Gran Canaria Dr Negrin, Serv Inmunol, Las Palmas Gran Canaria, Spain
Mangialasche, Francesca:: 118 Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden
Jessen, Frank:: 119 Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Cologne, Germany

120 Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany

56 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Nicolas, Gael:: 76 Hosp Cabuenes, Gijon, Spain
Selbak, Geir:: 121 Vestfold Hosp Trust, Norwegian Natl Advisory Unit Ageing & Hlth, Tonsberg, Norway

122 Oslo Univ Hosp, Dept Geriatr Med, Oslo, Norway

123 Univ Oslo, Inst Clin Med, Oslo, Norway
Ortega, Gemma:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Chene, Genevieve:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hadjigeorgiou, Georgios:: 124 Univ Cyprus, Sch Med, Dept Neurol, Nicosia, Cyprus
Rossi, Giacomina:: 114 Fdn IRCCS Ist Neurol Carlo Besta, Milan, Italy
Spalletta, Gianfranco:: 125 IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy

126 Baylor Coll Med, Dept Psychiat & Behav Sci, Beth K & Stuart C Yudofsky Div Neuropsychiat, Houston, TX 77030 USA
Giaccone, Giorgio:: 114 Fdn IRCCS Ist Neurol Carlo Besta, Milan, Italy
Grande, Giulia:: 127 Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

128 Stockholm Univ, Stockholm, Sweden
Binetti, Giuliano:: 129 IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, MAC Memory Clin, Brescia, Italy

130 IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy
Papenberg, Goran:: 127 Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

128 Stockholm Univ, Stockholm, Sweden
Hampel, Harald:: 131 Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Alzheimer Precis Med,GRC 21, Paris, France
Bailly, Henri:: 111 Hop Broca, APHP, Paris, France

132 Univ Paris 05, Sorbonne Paris Cite, EA 4468, Paris, France
Zetterberg, Henrik:: 133 Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

134 Univ Gothenburg, Dept Psychiat & Neurochemi, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden
Soininen, Hilkka:: 137 Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland

138 Kuopio Univ Hosp, Neurol, Neuroctr, Kuopio, Finland
Karlsson, Ida K:: 11 Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

139 Jonkoping Univ, Inst Gerontol & Aging Res Network Jonkoping ARN J, Jonkoping, Sweden
Alvarez, Ignacio:: 38 Fundacio Docencia & Recerca MutuaTerrassa, Barcelona, Spain

39 Hosp Univ Mutua Terrassa, Memory Disorders Unit, Dept Neurol, Barcelona, Spain
Appollonio, Ildebrando:: 104 Univ Milano Bicocca, Sch Med & Surg, Milan, Italy

105 Milan Ctr Neurosci, Milan, Italy

140 San Gerardo Hosp, Neurol Unit, Monza, Italy
Giegling, Ina:: 6 Delft Univ Technol, Delft Bioinformat Lab, Delft, Netherlands
Skoog, Ingmar:: 13 Univ Gothenburg, Ctr Ageing & Hlth AgeCap, Neuropsychiat Epidemiol Unit,Sahlgrenska Acad, Dept Psychiat & Neurochem,Inst Neurosci & Physiol, Gothenburg, Sweden
Saltvedt, Ingvild:: 141 Univ Hosp Trondheim, Dept Geriatr, Med Clin, St Olavs Hosp, Trondheim, Norway

142 Norwegian Univ Sci & Technhol NTNU, Dept Neuromed & Movement Sci, Trondheim, Norway
Rainero, Innocenzo:: 143 Univ Torino, Dept Neurosci Rita Levi Montalcini, Turin, Italy
Rosas Allende, Irene:: 144 Hosp Univ Cent Asturias, Lab Genet, Oviedo, Spain

27 Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain
Hort, Jakub:: 145 Charles Univ Prague, Fac Med 2, Memory Clin, Dept Neurol, Prague, Czech Republic
Diehl-Schmid, Janine:: 148 Tech Univ Munich, Klinikum Rechts Isar, Sch Med, Dept Psychiat & Psychotherapy, Munich, Germany
Van Dongen, Jasper:: 84 VIB Ctr Mol Neurol, Antwerp, Belgium

85 Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium
Vidal, Jean-Sebastien:: 111 Hop Broca, APHP, Paris, France

132 Univ Paris 05, Sorbonne Paris Cite, EA 4468, Paris, France
Lehtisalo, Jenni:: 137 Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland

149 Finnish Inst Hlth & Welf, Populat Hlth Unit, Helsinki, Finland
Wiltfang, Jens:: 150 Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

151 German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

152 Univ Aveiro, Dept Med Sci, Neurosci & Signaling Grp, Inst Biomed iBiMED, Aveiro, Portugal
Thomassen, Jesper Qvist:: 58 Rigshosp, Dept Clin Biochem, Copenhagen, Denmark
Kornhuber, Johannes:: 153 Friedrich Alexander Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany
Haines, Jonathan L:: 154 Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

155 Case Western Reserve Univ, Cleveland Inst Computat Biol, Cleveland, OH 44106 USA
Vogelgsang, Jonathan:: 150 Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

156 Harvard Med Sch, McLean Hosp, Translat Neurosci Lab, Belmont, MA USA
Pineda, Juan A:: 24 Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Fortea, Juan:: 25 Univ Autonoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Popp, Julius:: 157 Univ Hosp Psychiat Zurich, Dept Geriatr Psychiat, Zurich, Switzerland

158 Univ Zurich, Zurich, Switzerland

159 Univ Hosp Lausanne, Old Age Psychiat, Lausanne, Switzerland
Deckert, Jurgen:: 160 Univ Hosp, Ctr Mental Hlth, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany
Buerger, Katharina:: 161 Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany

162 German Ctr Neurodegenerat Dis DZNE, Munich, Germany
Morgan, Kevin:: 163 Univ Nottingham, Sch Life Sci, Nottingham, England

164 Univ Nottingham, Sch Med, Nottingham, England
FlieSSbach, Klaus:: 9 Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Sleegers, Kristel:: 84 VIB Ctr Mol Neurol, Antwerp, Belgium

85 Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium

86 Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Molina-Porcel, Laura:: 107 Hosp Clin Barcelona, IDIBAPS, Neurol Tissue Bank Biobanc, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain

15 Univ Barcelona, Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Serv Neurol,Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
Kilander, Lena:: 165 Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden
Weinhold, Leonie:: 166 Univ Hosp Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany
Farrer, Lindsay A:: 167 Boston Univ, Sch Med, Dept Med Biomed Genet, Boston, MA 02118 USA

168 Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

169 Boston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA

170 Boston Univ, Sch Med, Dept Epidemiol, Boston, MA 02118 USA

171 Boston Univ, Sch Med, Dept Biostat, Boston, MA 02118 USA

172 Boston Univ, Sch Publ Hlth, Boston, MA USA
Wang, Li-San:: 46 Univ Penn, Dept Pathol & Lab Med, Penn Neurodegenerat Genom Ctr, Perelman Sch Med, Philadelphia, PA USA
Kleineidam, Luca:: 8 Univ Cologne, Fac Med, Div Neurogenet & Mol Psychiat, Dept Psychiat & Psychotherapy, Cologne, Germany

9 Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Farotti, Lucia:: 173 Univ Perugia, Lab Clin Neurochem, Ctr Memory Disturbances, Neurol Sect, Perugia, Italy
Parnetti, Lucilla:: 173 Univ Perugia, Lab Clin Neurochem, Ctr Memory Disturbances, Neurol Sect, Perugia, Italy
Tremolizzo, Lucio:: 104 Univ Milano Bicocca, Sch Med & Surg, Milan, Italy

105 Milan Ctr Neurosci, Milan, Italy

140 San Gerardo Hosp, Neurol Unit, Monza, Italy
Hausner, Lucrezia:: 174 Heidelberg Univ, Med Fac Mannheim, Dept Geriatr Psychiat, Cent Inst Mental Hlth Mannheim, Heidelberg, Germany
Benussi, Luisa:: 130 IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy
Froelich, Lutz:: 174 Heidelberg Univ, Med Fac Mannheim, Dept Geriatr Psychiat, Cent Inst Mental Hlth Mannheim, Heidelberg, Germany
Ikram, M Arfan:: 175 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
Deniz-Naranjo, M Candida:: 117 Hosp Univ Gran Canaria Dr Negrin, Serv Inmunol, Las Palmas Gran Canaria, Spain
Tsolaki, Magda:: 176 Aristotle Univ Thessaloniki, Dept Neurol 1, Thessaloniki, Greece
Rosende-Roca, Maitee:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Lowenmark, Malin:: 165 Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden
Hulsman, Marc:: 4 Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

5 Vrije Univ Amsterdam, Sect Genom Neurodegenerat Dis & Aging, Dept Clin Genet, Amsterdam UMC, Amsterdam, Netherlands
Spallazzi, Marco:: 177 Azienda Osped Univ, Parma, Italy
Pericak-Vance, Margaret A:: 72 Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA
Esiri, Margaret:: 178 Nuffield Dept Clin Neurosci, Oxford, England
Bernal Sanchez-Arjona, Maria:: 23 Univ Seville, CSIC, Inst Biomed Sevilla IBiS, Unidad Demencias,Serv Neurol & Neurofisiol,Hosp U, Seville, Spain
Dalmasso, Maria Carolina:: 8 Univ Cologne, Fac Med, Div Neurogenet & Mol Psychiat, Dept Psychiat & Psychotherapy, Cologne, Germany
Martinez-Larrad, Maria Teresa:: 62 Hosp Clin San Carlos IdISSC, Inst Invest Sanitaria, Madrid, Spain

63 Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid, Spain
Arcaro, Marina:: 94 Fdn IRCCS Ca Granda Osped Policlin, Milan, Italy
Nothen, Markus M:: 179 Univ Bonn, Inst Human Genet, Sch Med, Bonn, Germany

180 Univ Hosp Bonn, Bonn, Germany
Fernandez-Fuertes, Marta:: 24 Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Dichgans, Martin:: 161 Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany

162 German Ctr Neurodegenerat Dis DZNE, Munich, Germany

181 Munich Cluster Syst Neurol SyNergy, Munich, Germany
Ingelsson, Martin:: 165 Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden
Herrmann, Martin J:: 160 Univ Hosp, Ctr Mental Hlth, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany
Scherer, Martin:: 182 Univ Med Ctr Hamburg Eppendorf, Dept Primary Med Care, Hamburg, Germany
Vyhnalek, Martin:: 145 Charles Univ Prague, Fac Med 2, Memory Clin, Dept Neurol, Prague, Czech Republic

146 Charles Univ Prague, Motol Univ Hosp, Prague, Czech Republic

147 St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic
Kosmidis, Mary H:: 183 Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Greece
Yannakoulia, Mary:: 184 Harokopio Univ, Dept Nutr & Dietet, Athens, Greece
Schmid, Matthias:: 166 Univ Hosp Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany

56 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Ewers, Michael:: 161 Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany

162 German Ctr Neurodegenerat Dis DZNE, Munich, Germany
Heneka, Michael T:: 56 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

9 Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Wagner, Michael:: 56 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

9 Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Scamosci, Michela:: 185 Univ Perugia, Inst Gerontol & Geriatr, Dept Med, Perugia, Italy
Kivipelto, Miia:: 118 Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden

186 Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland

187 Imperial Coll London, Neuroepidemiol & Ageing Res Unit, Sch Publ Hlth, London, England

188 Stockholms Sjukhem, Res & Dev Unit, Stockholm, Sweden
Hiltunen, Mikko:: 189 Univ Eastern Finland, Inst Biomed, Kuopio, Finland
Zulaica, Miren:: 3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

34 Inst Biodonostia, Neurosci Area, San Sebastian, Spain
Alegret, Montserrat:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Fornage, Myriam:: 190 Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, Houston, TX 77030 USA
Roberto, Natalia:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
van Schoor, Natasja M:: 12 Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Data Sci, Amsterdam, Netherlands
Seidu, Nazib M:: 13 Univ Gothenburg, Ctr Ageing & Hlth AgeCap, Neuropsychiat Epidemiol Unit,Sahlgrenska Acad, Dept Psychiat & Neurochem,Inst Neurosci & Physiol, Gothenburg, Sweden
Banaj, Nerisa:: 125 IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy
Armstrong, Nicola J:: 16 Murdoch Univ, Math & Stat, Perth, WA, Australia
Scarmeas, Nikolaos:: 191 Natl & Kapodistrian Univ Athens, Dept Neurol 1, Aiginit Hosp, Sch Med, Athens, Greece

192 Columbia Univ, Gertrude H Sergievsky Ctr, Depatment Neurol, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10027 USA
Scherbaum, Norbert:: 193 Univ Duisburg Essen, LVR Hosp Essen, Dept Psychiat & Psychotherapy, Fac Med, Essen, Germany
Goldhardt, Oliver:: 148 Tech Univ Munich, Klinikum Rechts Isar, Sch Med, Dept Psychiat & Psychotherapy, Munich, Germany
Hanon, Oliver:: 111 Hop Broca, APHP, Paris, France

132 Univ Paris 05, Sorbonne Paris Cite, EA 4468, Paris, France
Peters, Oliver:: 194 Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

195 Charite Univ Med Berlin, Expt & Clin Res Ctr ECRC, Berlin, Germany

196 German Ctr Neurodegenerat Dis DZNE, Berlin, Germany
Skrobot, Olivia Anna:: 197 Univ Bristol, Southmead Hosp, Bristol Med Sch THS, Bristol, Avon, England
Quenez, Olivier:: 73 Normandie Univ, UNIROUEN, INSERM, CHU Rouen,Dept Genet,U1245, F-76000 Rouen, France
Lerch, Ondrej:: 145 Charles Univ Prague, Fac Med 2, Memory Clin, Dept Neurol, Prague, Czech Republic

146 Charles Univ Prague, Motol Univ Hosp, Prague, Czech Republic

147 St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic
Bosso, Paola:: 198 IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Expt Neuropsychobiol Lab, Rome, Italy
Caffarra, Paolo:: 199 Univ Parma, DIMEC, Unit Neurosci, Parma, Italy
Dionigi Rossi, Paolo:: 67 IRCCS Osped Maggiore Policlin, Fdn Ca Granda, Geriatr Unit, Milan, Italy
Sakka, Paraskevi:: 200 Athens Assoc Alzheimers Dis & Related Disorders, Athens, Greece
Hoffmann, Per:: 179 Univ Bonn, Inst Human Genet, Sch Med, Bonn, Germany

180 Univ Hosp Bonn, Bonn, Germany

201 Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland
Holmans, Peter A:: 18 Cardiff Univ, Div Psychol Med & Clinial Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Fischer, Peter:: 202 Social Med Ctr East Donauspital, Dept Psychiat, Vienna, Austria
Riederer, Peter:: 203 Univ Hosp Wurzburg, Clin & Policlin Psychiat Psychosomat & Psychother, Ctr Mental Hlth, Wurzburg, Germany
Yang, Qiong:: 55 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
Marshall, Rachel:: 18 Cardiff Univ, Div Psychol Med & Clinial Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Kalaria, Rajesh N:: 204 Newcastle Univ, Translat & Clincial Res Inst, Newcastle Upon Tyne, Tyne & Wear, England

205 Campus Ageing Anf Vital, Newcastle Upon Tyne, Tyne & Wear, England
Mayeux, Richard:: 206 Columbia Univ, Dept Neurol, Taub Inst Alzheimers Dis & Aging Brain, New York, NY USA

207 Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA

208 Columbia Univ, Dept Neurol, New York, NY USA
Vandenberghe, Rik:: 209 Univ Leuven, Dept Neurosci, Lab Cognit Neurol, Leuven, Belgium

210 Univ Hosp Leuven, Dept Neurol, Leuven, Belgium
Cecchetti, Roberta:: 185 Univ Perugia, Inst Gerontol & Geriatr, Dept Med, Perugia, Italy
Ghidoni, Roberta:: 130 IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy
Frikke-Schmidt, Ruth:: 58 Rigshosp, Dept Clin Biochem, Copenhagen, Denmark

59 Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark
Sorbi, Sandro:: 68 Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy

69 IRCCS Fdn Don Carlo Gnocchi, Florence, Italy
Hagg, Sara:: 11 Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
Engelborghs, Sebastiaan:: 211 Vrije Univ Brussel, Ctr Neurosci, Brussels, Belgium

212 Univ Antwerp, Reference Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium

213 Univ Antwerp, Inst Born Bunge, Antwerp, Belgium

214 VUB Univ Hosp Brussels UZ Brussel, Dept Neurol, Brussels, Belgium
Helisalmi, Seppo:: 215 Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland
Botne Sando, Sigrid:: 216 Univ Hosp Trondheim, Dept Neurol & Clin Neurophysiol, Trondheim, Norway

217 Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci, Trondheim, Norway
Kern, Silke:: 13 Univ Gothenburg, Ctr Ageing & Hlth AgeCap, Neuropsychiat Epidemiol Unit,Sahlgrenska Acad, Dept Psychiat & Neurochem,Inst Neurosci & Physiol, Gothenburg, Sweden
Archetti, Silvana:: 218 Brescia Hosp, Lab Anal 3, Dept Lab Diagnost, Brescia, Italy
Boschi, Silvia:: 143 Univ Torino, Dept Neurosci Rita Levi Montalcini, Turin, Italy
Fostinelli, Silvia:: 130 IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy
Gil, Silvia:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Mendoza, Silvia:: 219 Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain

220 Andalusian Inst Neurosci, Memory Clin, Malaga, Spain
Mead, Simon:: 221 UCL, Inst Prion Dis, MRC Prion Unit, London, England
Ciccone, Simona:: 67 IRCCS Osped Maggiore Policlin, Fdn Ca Granda, Geriatr Unit, Milan, Italy
Djurovic, Srdjan:: 222 Oslo Univ Hosp, Dept Med Genet, Oslo, Norway

223 Univ Bergen, NORMENT, Dept Clin Sci, Bergen, Norway
Heilmann-Heimbach, Stefanie:: 179 Univ Bonn, Inst Human Genet, Sch Med, Bonn, Germany

180 Univ Hosp Bonn, Bonn, Germany
Riedel-Heller, Steffi:: 224 Univ Leipzig, Inst Social Med Occupat Hlth & Publ Hlth, Leipzig, Germany
Kuulasmaa, Teemu:: 189 Univ Eastern Finland, Inst Biomed, Kuopio, Finland
Del Ser, Teodoro:: 225 Queen Sofia Fdn Alzheimer Ctr, Dept Neurol, CIEN Fdn, Madrid, Spain
Lebouvier, Thibaud:: 115 Univ Lille, LiCEND, INSERM, CHU,DISTAlz,U1172, Lille, France
Polak, Thomas:: 160 Univ Hosp, Ctr Mental Hlth, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany
Ngandu, Tiia:: 118 Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden

149 Finnish Inst Hlth & Welf, Populat Hlth Unit, Helsinki, Finland
Grimmer, Timo:: 148 Tech Univ Munich, Klinikum Rechts Isar, Sch Med, Dept Psychiat & Psychotherapy, Munich, Germany
Bessi, Valentina:: 226 Azienda Osped Univ Careggi Largo Brambilla, Florence, Italy

68 Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy
Escott-Price, Valentina:: 18 Cardiff Univ, Div Psychol Med & Clinial Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, Wales

227 Cardiff Univ, UKDRI Cardiff, Cardiff, Wales
Giedraitis, Vilmantas:: 165 Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden
Deramecourt, Vincent:: 115 Univ Lille, LiCEND, INSERM, CHU,DISTAlz,U1172, Lille, France

116 CHU CNR MAJ, Lille, France
Maier, Wolfgang:: 56 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

9 Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Jian, Xueqiu:: 88 Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA
Pijnenburg, Yolande A L:: 4 Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Kehoe, Patrick Gavin:: 196 German Ctr Neurodegenerat Dis DZNE, Berlin, Germany
Garcia-Ribas, Guillermo:: 42 Hosp Univ Ramon y Cajal, IRYCIS, Madrid, Spain
Sanchez-Juan, Pascual:: 3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

40 Univ Cantabria, Univ Hosp, Neurol Serv, Marques de Valdecilla Univ Hosp, Santander, Spain

41 IDIVAL, Santander, Spain
Pastor, Pau:: 38 Fundacio Docencia & Recerca MutuaTerrassa, Barcelona, Spain

39 Hosp Univ Mutua Terrassa, Memory Disorders Unit, Dept Neurol, Barcelona, Spain
Perez-Tur, Jordi:: 228 CSIC, Inst Biomed Valencia, Unitat Genet Mol, Valencia, Spain

Instituto de Investigación. 229 Inst Invest Sanitaria La Fe, Unidad Mixta Neurol Genet, Valencia, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Pinol-Ripoll, Gerard:: 35 Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain

36 Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain
Lopez de Munain, Adolfo:: 230 Univ Basque Country, Dept Neurosci, Fac Med & Nursery, San Sebastian, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

33 Hosp Univ Donostia, Dept Neurol, San Sebastian, Spain

34 Inst Biodonostia, Neurosci Area, San Sebastian, Spain
Garcia-Alberca, Jose Maria:: 219 Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain

220 Andalusian Inst Neurosci, Memory Clin, Malaga, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Bullido, Maria J:: 231 UAM, Ctr Biol Mol Severo Ochoa, CSIC, Madrid, Spain

232 Inst Invest Sanitaria Hosp la Paz IdIPaz, Madrid, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

31 Univ Autonoma Madrid, Madrid, Spain
Alvarez, Victoria:: 144 Hosp Univ Cent Asturias, Lab Genet, Oviedo, Spain

27 Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain
Lleo, Alberto:: 25 Univ Autonoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Real, Luis M:: 233 Univ Malaga, Fac Med, Dept Especialidades Quirurg Bioquim & Inmunol, Malaga, Spain

24 Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Mir, Pablo:: 3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

91 Univ Seville, CSIC, Inst Biomed Sevilla IBiS,Hosp Univ Virgen del Roc, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Medina, Miguel:: 22 Queen Sofia Fdn Alzheimer Ctr, CIEN Fdn, Madrid, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Scheltens, Philip:: 4 Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Holstege, Henne:: 4 Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

5 Vrije Univ Amsterdam, Sect Genom Neurodegenerat Dis & Aging, Dept Clin Genet, Amsterdam UMC, Amsterdam, Netherlands
Marquie, Marta:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Saez, Maria Eugenia:: 20 Ctr Andaluz Estudios Bioinformat, Seville, Spain
Carracedo, Angel:: 19 Univ Santiago de Compostela, Grp Med Xenom, Ctr Nacl Genotipado CEGEN PRB3 ISCIII, Santiago De Compostela, Spain

234 Fdn Publ Galega Med Xen CIBERER IDIS, Santiago De Compostela, Spain
Amouyel, Philippe:: 7 Univ Lille, Inst Pasteur Lille, INSERM, CHU Lille,U1167 Labex DISTALZ RID AGE Risk Factor, Lille, France
Schellenberg, Gerard D:: 46 Univ Penn, Dept Pathol & Lab Med, Penn Neurodegenerat Genom Ctr, Perelman Sch Med, Philadelphia, PA USA
Williams, Julie:: 18 Cardiff Univ, Div Psychol Med & Clinial Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, Wales

52 Cardiff Univ, UK Dementia Res Inst Cardiff, Cardiff, Wales
Seshadri, Sudha:: 235 Framingham Heart Dis Epidemiol Study, Framingham, MA USA

54 Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

88 Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA
van Duijn, Cornelia M:: 175 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

236 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
Mather, Karen A:: 237 Univ New South Wales, Fac Med, Sch Psychiat, Ctr Hlth Brain Ageing CHeBA, Sydney, NSW, Australia

238 Neurosci Res Australia, Sydney, NSW, Australia
Sanchez-Valle, Raquel:: 15 Univ Barcelona, Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Serv Neurol,Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
Serrano-Rios, Manuel:: 62 Hosp Clin San Carlos IdISSC, Inst Invest Sanitaria, Madrid, Spain

63 Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid, Spain
Orellana, Adelina:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Tarraga, Lluis:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Blennow, Kaj:: 133 Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

134 Univ Gothenburg, Dept Psychiat & Neurochemi, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden
Huisman, Martijn:: 12 Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Data Sci, Amsterdam, Netherlands

239 Vrije Univ Amsterdam, Dept Sociol, Amsterdam, Netherlands
Andreassen, Ole A:: 240 Univ Oslo, Inst Clin Med, NORMENT Ctr, Oslo, Norway
Posthuma, Danielle:: 10 Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Complex Trait Genet, Amsterdam Neurosci, Amsterdam, Netherlands
Clarimon, Jordi:: 25 Univ Autonoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Boada, Merce:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
van der Flier, Wiesje M:: 4 Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Ramirez, Alfredo:: 242 Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, Dept Psychiat, San Antonio, TX USA

56 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

8 Univ Cologne, Fac Med, Div Neurogenet & Mol Psychiat, Dept Psychiat & Psychotherapy, Cologne, Germany

9 Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Lambert, Jean-Charles:: 7 Univ Lille, Inst Pasteur Lille, INSERM, CHU Lille,U1167 Labex DISTALZ RID AGE Risk Factor, Lille, France
van der Lee, Sven J:: 4 Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

5 Vrije Univ Amsterdam, Sect Genom Neurodegenerat Dis & Aging, Dept Clin Genet, Amsterdam UMC, Amsterdam, Netherlands
Ruiz, Agustin:: 1 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain

2 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

3 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Keywords

SUSCEPTIBILITY LOCI; FAMILY-HISTORY; METAANALYSIS; IMMUNITY; AGE

Campos de estudio

Proyectos asociados

COMPREHENSIVE, INTEGRATIVE AND GENOMIC APPROACH TO THE UNDERSTANDING AND TREATMENT OF CANCER AND LEUKEMIA.

Investigador Principal: MIGUEL ÁNGEL SANZ ALONSO

PIE13/00046 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2014

Cita

Cita Bibliográfica

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