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  3. Is processing speed a valid neurocognitive endophenotype in bipolar disorder? Evidence from a longitudinal, family study

Is processing speed a valid neurocognitive endophenotype in bipolar disorder? Evidence from a longitudinal, family study

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Correa-Ghisays, P
  • Vila-Frances, J
  • Selva-Vera, G
  • Salazar-Fraile, J
  • Cardoner, N
  • Ruiz-Veguilla, M
  • Tabares-Seisdedos, R

Grupos

Abstract

Background: Substantial evidence supports the existence of neurocognitive endophenotypes in bipolar disorder (BD), but very few longitudinal studies have included unaffected relatives. In a 5-year, follow-up, family study, we have recently suggested that deficits in manual motor speed and visual memory could be endophenotype candidates for BD. We aimed to explore whether this also applies to processing speed. Methods: A sample of 348 individuals, including 163 BD patients, 65 unaffected first-degree relatives (BD-Rel) and 120 genetically unrelated healthy controls (HC), was assessed with the Digit Symbol Substitution Test (DSST) on two occasions over a 2-year period (T1, T2). DSST values were controlled for age, years of education, occupational status, and subsyndromic mood symptoms. Differences between groups were evaluated with ANCOVAs. Results: At T1 BD performed significantly worse than HC (p < 0.001; Cohen's d = 1.38) and BD-Rel (p < 0.001; Cohen's d = 0.82). BD-Rel showed an intermediate performance with significant differences with HC (p < 0.01; Cohen's d = 0.50). Similarly, at T2 BD performed significantly worse than HC (p < 0.001; Cohen's d = 1.44) and BD-Rel (p < 0.01; Cohen's d = 0.51). BD-Rel performance was intermediate and significantly lower than that of HC (p < 0.01; Cohen's d = 0.97). A Repeated Measures ANOVA revealed no significant between-group differences in performance over time (p > 0.05). Conclusions: The results of this longitudinal, family study suggest that impaired processing speed may represent a suitable cognitive endophenotype for BD. Further research on the field is required to confirm these preliminary findings.

Datos de la publicación

ISSN/ISSNe:
0022-3956, 1879-1379

JOURNAL OF PSYCHIATRIC RESEARCH  PERGAMON-ELSEVIER SCIENCE LTD

Tipo:
Article
Páginas:
241-247
Factor de Impacto:
1,560 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 9

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Keywords

  • Bipolar disorder; Cognition; Endophenotype; Processing speed; Longitudinal study; Family study

Financiación

Instituto de Salud Carlos IIIInstituto de Salud Carlos IIIEuropean Commission

Proyectos asociados

EFECTOS DE LA MONOTERAPIA CON LITIO EN EL FUNCIONAMIENTO NEUROPSICOLOGICO DE LOS PACIENTES CON TRASTORNO BIPOLAR

Investigador Principal: LORENZO LIVIANOS ALDANA

SM I 22/2011 . 2012

CON-CIENCIA-YV: PILDORAS DE SALUD

FCT-13-7457_FECYT_2013 . MINISTERIO DE ECONOMIA Y COMPETITIVIDAD; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2013

CARACTERIZACIÓN EPIGENÓMICA DE LA ANOREXIA NERVIOSA. MODELO DE GEMELAS MONOCIGOTAS DISCORDANTES Y VALIDACIÓN EN POBLACIÓN GENERAL.

Investigador Principal: LUIS MIGUEL ROJO MORENO

PI16/01279 . INSTITUTO DE SALUD CARLOS III . 2017

INFLAMACIÓN, DISBIOSIS Y TRASLOCACIÓN BACTERIANA EN TRASTORNO BIPOLAR Y ESQUIZOFRENIA: INFLUENCIA DEL ESTILO DE VIDA. ESTUDIO PROBILIFE.

Investigador Principal: VICENT BALANZA MARTINEZ

PI16/01770 . INSTITUTO DE SALUD CARLOS III . 2017

ESTUDIO MULTICENTRICO, DOBLE CIEGO, ALEATORIZADO COMPARANDO CON PLACEBO PARA EVALUAR LA EFICACIA Y SEGURIDAD DE LAMOTRIGINA A DOSIS FIJA COMO TRATAMIENTO COMPLEMENTARIO AL LITIO EN EL TRATAMIENTO DE LA DEPRESION BIPOLAR SEGUIDO DE UN TRATAMIENTO PREVENTIVO A LARGO PLAZO DE LA RECAIDA Y LA RECURRENCIA DE DEPRESION Y/O MANIA EN PACIENTES CON TRANSTORNO BIPOLAR.

Investigador Principal: LORENZO LIVIANOS ALDANA

SCA30905

ESTUDIO OBSERVACIONAL EUROPEO DE LOS RESULTADOS SANITARIOS EN EL TRATAMIENTO DEL EPISODIO MANIACO DEL TRASTORNO BIPOLAR.

Investigador Principal: LORENZO LIVIANOS ALDANA

FID-EW-HGKV

ESTUDIO ALEATORIZADO, DE GRUPOS PARALELOS, ABIERTO QUE EXAMINA LA SEGURIDAD, EFICACIA Y TOLERABILIDAD DE LA TITULACION RAPIDA 800 MG/DIA AL CUARTO DIA DE DUMARATO DE QUETIAPINA COMPARADO CON LA TITULACION ESTANDAR 400 MG/DIA AL 4º DIA EN EL TRATAMIENTO DEL EPISODIO MANIACO BIPOLAR.

Investigador Principal: LORENZO LIVIANOS ALDANA

D1449C00005

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