Rationale and design of the rigorous atrial analysis in advanced interatrial block (ARABIA) prospective study

Fecha de publicación: 01/09/2021 Fecha Ahead of Print: 12/08/2021

Autores de IIS La Fe

Miguel Ángel Arnau Vives

Autor

Participantes ajenos a IIS La Fe

Martinez-Selles, M
Bruna, V
Lacalzada-Almeida, J
Diez-Villanueva, P
Ruiz-Ortiz, M
Alzola, E
Tobar, J
Hernandez, JM
Bonet, A
Castro, V
Rubin, JM
Garcia-Martin, A
Perez-David, E

Grupos

Grupo de Investigación Clínica y Traslacional en Cardiología

Investigador Principal

Esther Roselló Lletí

Abstract

Background: Advanced interatrial block (IAB) is present in 10% of subjects >_75 years and is associated with the risk of clinical events. Methods and results: Prospective multicenter study that will include subjects >_75 years without exclusion criteria (indication for anticoagulation, cardiac devices, severe valve disease, systolic dysfunction, moderate or severe cognitive impairment, poor echocardiographic window, non-sinus rhythm or partial IAB, stroke, and life expectancy <2 years). A total of 356 subjects, 178 patients with advanced IAB (exposed) and 178 matched individuals with normal P-wave (non-exposed) will be included. Electrocardiogram and advanced transthoracic echocardiography will be performed. Two substudies will include magnetic resonance imaging: cardiac (86 subjects, 43 exposed, and 43 non-exposed) and brain (86 subjects, 43 exposed, and 43 non-exposed). The follow-up will be 2 years. Our main objective is to determine the association of advanced IAB, P-wave duration, and atrial imaging parameters (I] atrial global longitudinal strain, II] maximal left atrial volume index, III] left atrial ejection fraction, IV] left atrial fibrosis -% total left atrial area V] inter-and intra-atrial asynchrony/dyssynchrony) with clinical events (atrial fibrillation, stroke, cognitive impairment, and mortality). The secondary objective is to assess the association of the P-wave duration with atrial imaging parameters and of both with cerebral microemboli in magnetic resonance imaging. Conclusion: Our study will provide data regarding the association of advanced IAB, P-wave duration, and atrial imaging parameters with clinical events. We will also assess the association P-wave duration-atrial imaging parameters-cerebral microemboli. (c) 2021 Elsevier Inc. All rights reserved.

Datos de la publicación

ISSN/ISSNe:: 0022-0736, 1532-8430
Tipo:: Article
Páginas:: 135-140
DOI:: 10.1016/j.jelectrocard.2021.08.007
PubMed:: 34419649
Factor de Impacto:: 0,419 SCImago ℠
Cuartil:: Q3 SCImago ℠

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Filiaciones

Martinez-Selles, M:: Univ Complutense, Hosp Gen Univ Gregorio Maranon, Serv Cardiol, Univ Europea, Madrid, Spain

Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain

Univ Gregorio Maranon, Gen Hosp, Serv Cardiol, C Dr Esquerdo,46, Madrid 28007, Spain
Bruna, V:: Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain

Univ Hosp, Serv Cardiol, Madrid, Spain
Lacalzada-Almeida, J:: Hosp Univ Canarias La Laguna, Serv Cardiol, Lab Imagen Cardiaca, Tenerife, Spain
Diez-Villanueva, P:: Hosp Univ Princesa, Serv Cardiol, Madrid, Spain
Ruiz-Ortiz, M:: Hosp Univ Reina Sofia, Serv Cardiol, Cordoba, Spain
Alzola, E:: Hosp Univ Cruces, Serv Cardiol, Baracaldo, Spain
Arnau, MA:: Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain

Hosp Univ & Politecn La Fe, Serv Cardiol, Valencia, Spain
Tobar, J:: Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain

Hosp Clin Univ Valladolid, Serv Cardiol, Valladolid, Spain
Hernandez, JM:: Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain

Hosp Clin Univ Salamanca, Serv Cardiol, Salamanca, Spain
Bonet, A:: Hosp Univ Santa Creu Sant Pau, Serv Cardiol, Barcelona, Spain
Castro, V:: Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain

Hosp Univ Puerta Hierro, Serv Cardiol, Madrid, Spain
Rubin, JM:: Hosp Univ Cent Asturias, Serv Cardiol, Oviedo, Spain
Garcia-Martin, A:: Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain

Hosp Univ Ramon & Cajal, Serv Cardiol, Madrid, Spain
Perez-David, E:: Hosp Univ La Paz, Serv Cardiol, Madrid, Spain