Portal de investigación
Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil Components: An In Vitro and In Vivo Study
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Poyatos-Racionero, Elisa
- Gonzalez-Alvarez, Isabel
- Sanchez-Moreno, Paola
- Sitia, Leopoldo
- Gatto, Francesca
- Pompa, Pier Paolo
- Gonzalez-Alvarez, Marta
- Bernardos, Andrea
Grupos
Abstract
Mesoporous silica microparticles functionalized with lactose for the specific release of essential oil components (EOCs) in the small intestine are presented. In vitro and in vivo intestinal models were applied to validate the microparticles (M41-EOC-L), in which the presence of lactase acts as the triggering stimulus for the controlled release of EOCs. Among the different microdevices prepared (containing thymol, eugenol and cinnamaldehyde), the one loaded with cinnamaldehyde showed the most significant Caco-2 cell viability reduction. On the other hand, interaction of the particles with enterocyte-like monolayers showed a reduction of EOCs permeability when protected into the designed microdevices. Then, a microdevice loaded with cinnamaldehyde was applied in the in vivo model of Wistar rat. The results showed a reduction in cinnamaldehyde plasma levels and an increase in its concentration in the lumen of the gastrointestinal tract (GIT). The absence of payload release in the stomach, the progressive release throughout the intestine and the prolonged stay of the payload in the GIT-lumen increased the bioavailability of the encapsulated compound at the site of the desired action. These innovative results, based on the specific intestinal controlled delivery, suggest that the M41-payload-L could be a potential hybrid microdevice for the protection and administration of bioactive molecules in the small intestine and colon.
Datos de la publicación
- ISSN/ISSNe:
- 1999-4923, 1999-4923
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 34209675
- Factor de Impacto:
- 0,922 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Pharmaceutics Multidisciplinary Digital Publishing Institute (MDPI)
Citas Recibidas en Web of Science: 5
Documentos
- No hay documentos
Filiaciones
Keywords
- essential oil components; mesoporous silica microparticles; controlled release; small intestine; in vitro and in vivo intestinal models; lactase enzyme; molecular gates; enterocyte-like monolayers
Financiación
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Cita
Poyatos E,Gonzalez I,Sanchez P,Sitia L,Gatto F,Pompa PP,AZNAR E,Gonzalez M,MARTINEZ R,MARCOS MD,Bernardos A. Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil Components: An In Vitro and In Vivo Study. Pharmaceutics. 2021. 13. (7):982. IF:6,525. (1).