Biological properties of extracellular vesicles and their physiological functions.

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Yáñez-Mó M
  • Siljander PR
  • Andreu Z
  • Zavec AB
  • Borràs FE
  • Buzas EI
  • Buzas K
  • Casal E
  • Cappello F
  • Carvalho J
  • Colás E
  • Cordeiro-da Silva A
  • Fais S
  • Falcon-Perez JM
  • Ghobrial IM
  • Giebel B
  • Gimona M
  • Graner M
  • Gursel I
  • Gursel M
  • Heegaard NH
  • Hendrix A
  • Kierulf P
  • Kokubun K
  • Kosanovic M
  • Kralj-Iglic V
  • Krämer-Albers EM
  • Laitinen S
  • Lässer C
  • Lener T
  • Ligeti E
  • Line A
  • Lipps G
  • Llorente A
  • Lötvall J
  • Mancek-Keber M
  • Mittelbrunn M
  • Nazarenko I
  • Nolte-'t Hoen EN
  • Nyman TA
  • O'Driscoll L
  • Olivan M
  • Oliveira C
  • Pállinger É
  • Del Portillo HA
  • Reventós J
  • Rigau M
  • Rohde E
  • Sammar M
  • Sánchez-Madrid F
  • Santarém N
  • Schallmoser K
  • Ostenfeld MS
  • Stoorvogel W
  • Stukelj R
  • Van der Grein SG
  • Vasconcelos MH
  • Wauben MH
  • De Wever O

Abstract

In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.

Datos de la publicación

ISSN/ISSNe:
2001-3078, 2001-3078

Journal of Extracellular Vesicles  WILEY

Tipo:
Article
Páginas:
27066-27066
PubMed:
25979354
Factor de Impacto:
3,889 SCImago
Cuartil:
Q1 SCImago

Citas Recibidas en Web of Science: 3.257

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Keywords

  • eukaryote, exosome, extracellular vesicle, microparticle, microvesicle, physiology, prokaryote

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