Deciphering the role of PGRMC1 during human decidualization using an in vitro approach.

Autores de IIS La Fe

• Francisco Domínguez Hernández

  Autor

Participantes ajenos a IIS La Fe

• Salsano S
• González-Martín R
• Quiñonero A
• Pérez-Debén S

Grupos

• Biología Reproductiva y Bioingeniería en Reproducción Humana

  

  Leader

  Nicolás Garrido Puchalt

Abstract

Non-classical membrane progesterone receptor (mPRs) and PGRMC1 expression have been detected in endometrium, but their role in decidualization was not yet investigated. We previously demonstrated PGRMC1 downregulation in receptive endometrium and that its overexpression inhibits decidualization. Furthermore, during decidualization, PGRMC1 mainly interacts with proteins involved in biosynthesis, intracellular transport and mitochondrial activity.

Keywords

• PGRMC1, decidualization, endometrium, non-classical progesterone receptor, progesterone