Portal de investigación
The revised microRNA complement of Fasciola hepatica reveals a plethora of overlooked microRNAs and evidence for enrichment of immuno-regulatory microRNAs in extracellular vesicles
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Fromm B
- Hackenberg M
- Cantalapiedra F
- Bernal D
Grupos
Abstract
MicroRNAs (miRNAs) are gene regulators that have recently been shown to down-regulate the immune response via extracellular vesicles in the mammalian host of helminthic parasites. Using the miRNA prediction pipeline miRCandRef, we expanded the current miRNA set of the liver fluke Fasciola hepatica (Platyhelminthes, Trematoda) from 16 to 54 miRNAs (42 conserved and 13 novel). Comparing the cellular expression levels with extracellular vesicles, we found all miRNAs expressed and enriched for miRNAs with immuno-regulatory function, tissue growth and cancer. Our findings support the hypothesis that miRNAs are the molecular mediators of the previously demonstrated immune modulatory function of extracellular vesicles. (C) 2015 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0020-7519, 1879-0135
- Tipo:
- Article
- Páginas:
- 697-702
- PubMed:
- 26183562
- Factor de Impacto:
- 2,050 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
INTERNATIONAL JOURNAL FOR PARASITOLOGY ELSEVIER SCI LTD
Citas Recibidas en Web of Science: 54
Documentos
- No hay documentos
Filiaciones
Keywords
- Fasciola hepatica; Helminth; Extracellular vesicles; miRNA
Cita
Fromm B,TRELIS M,Hackenberg M,Cantalapiedra F,Bernal D,MARCILLA A. The revised microRNA complement of Fasciola hepatica reveals a plethora of overlooked microRNAs and evidence for enrichment of immuno-regulatory microRNAs in extracellular vesicles. Int. J. Parasit. 2015. 45. (11):p. 697-702. IF:4,242. (1).