A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging

Data de publicació: 01/05/2021 Data Ahead of Print: 27/04/2021

Autors de IIS La Fe

• Amadeo Ten Esteve

  Autor

• Sonia Gines Cardenas

  Autor

• 

  Luis Martí Bonmatí

  Autor

Autors aliens a IIS La Fe

• Orts-Arroyo, M
• Castro, I
• Martinez-Lillo, J

Grups d'Investigació

• Investigacion Biomédica en Imagen (GIBI 2-30)

  Investigador Principal

  Leonor Cerdá Alberich

Abstract

The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)(2)(H2O)(6)](ClO4)(3)center dot 2H(2)O (1) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase. 1 has been characterized through UV-vis, IR, SEM-EDAX, and single-crystal X-ray diffraction techniques, and its magnetic and relaxometric properties have been investigated by means of SQUID magnetometer and MR imaging phantom studies, respectively. On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast-enhanced magnetic resonance imaging.

Keywords

• thymine; gadolinium; contrast agent; magnetic resonance; metal complexes; crystal structure; relaxivity