Sister chromatid exchange, (SCE), High-Frequency Cells (HFCs) and SCE distribution patterns in peripheral blood lymphocytes of Spanish adult smokers compared to non-smokers

Autores de IIS La Fe

• Natividad Sebastiá Fabregat

  Autor

• David Hervás Marín

  Autor

• Miguel Jose Almonacid Bujeda

  Autor

• Juan Ignacio Villaescusa Blanca

  Autor

• José Miguel Soriano Del Castillo

  Autor

• Joan Francesc Barquinero Estruch

  Autor

• José Vicente Cervera Zamora

  Autor

• Esperanza Such Taboada

  Autor

• Alegría Montoro Pastor

  Autor

Participantes ajenos a IIS La Fe

• Sahuquillo V
• Esteban V
• Verdú G

Grupos

• Hematología y Hemoterapia

  

  Investigador Principal

  Javier De La Rubia Comos

• Investigacion Biomédica en Imagen (GIBI 2-30)

  Investigador Principal

  Leonor Cerdá Alberich

• Unidad Mixta de Investigación en Endocrinología, Nutrición y Dietética clínica

  Leader

  Juan Francisco Merino Torres

Abstract

According to the International Agency for Research on Cancer, smoking tobacco is a major cause of cancer in humans. It causes about half of all male cancer deaths and an ever increasing number of cancer deaths in females. The aim of this study was to establish whether cigarette smoking increases sister chromatid exchanges (SCEs) in peripheral blood lymphocytes in two Spanish population groups; light and heavy smokers. The mean number of High-Frequency Cells (HFCs) was determined and, the SCE distribution pattern among the chromosomes was analysed represented by a ratio described below. A local sample of 101 adult smokers (n = 48) and non-smokers (n = 53), aged from 18 to 49 years, was studied using SCE levels in peripheral lymphocytes. Heavy smoking (>= 10 cigarettes per day) increased significantly the SCE frequency and the HFC parameters. Neither age nor sex significantly influenced the frequencies in the groups studied. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.

Keywords

• Tobacco; Cytogenetic assessment; Biomarker; SCEs