1. Inicio
  2. Publicaciones
  3. Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry

Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Rubio-Rivas, M
  • Corbella, X
  • Formiga, F
  • Fernandez, EM
  • Escalante, MDM
  • Fernandez, IB
  • Fernandez, FA
  • Del Corral-Beamonte, E
  • Lalueza, A
  • Virto, AP
  • Vallejo, ER
  • Loureiro-Amigo, J
  • Suarez, AMA
  • Abadia-Otero, J
  • De La Chica, MN
  • Gonzalez, RE
  • Milian, AH
  • Manrique, MA
  • Encinar, JCB
  • Noya, AG
  • Ferrer, RG
  • Aguilera, MP
  • Nunez-Cortes, JM
  • Casas-Rojo, JM
  • SEMI-COVID-19 Network

Grupos

Abstract

(1) Background: The inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. (2) Methods: Retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lymphocyte count and the values of C-reactive protein, lactate dehydrogenase, ferritin, and D-dimer taken at the time of admission. (3) Results: A total of 17,122 patients were included in the study. The high-risk group was older (57.9 vs. 64.2 vs. 70.4 years; p < 0.001) and predominantly male (37.5% vs. 46.9% vs. 60.1%; p < 0.001). They had a higher degree of dependence in daily tasks prior to admission (moderate-severe dependency in 10.8% vs. 14.1% vs. 17%; p < 0.001), arterial hypertension (36.9% vs. 45.2% vs. 52.8%; p < 0.001), dyslipidemia (28.4% vs. 37% vs. 40.6%; p < 0.001), diabetes mellitus (11.9% vs. 17.1% vs. 20.5%; p < 0.001), ischemic heart disease (3.7% vs. 6.5% vs. 8.4%; p < 0.001), heart failure (3.4% vs. 5.2% vs. 7.6%; p < 0.001), liver disease (1.1% vs. 3% vs. 3.9%; p = 0.002), chronic renal failure (2.3% vs. 3.6% vs. 6.7%; p < 0.001), cancer (6.5% vs. 7.2% vs. 11.1%; p < 0.001), and chronic obstructive pulmonary disease (5.7% vs. 5.4% vs. 7.1%; p < 0.001). They presented more frequently with fever, dyspnea, and vomiting. These patients more frequently required high flow nasal cannula (3.1% vs. 4.4% vs. 9.7%; p < 0.001), non-invasive mechanical ventilation (0.9% vs. 3% vs. 6.3%; p < 0.001), invasive mechanical ventilation (0.6% vs. 2.7% vs. 8.7%; p < 0.001), and ICU admission (0.9% vs. 3.6% vs. 10.6%; p < 0.001), and had a higher percentage of in-hospital mortality (2.3% vs. 6.2% vs. 23.9%; p < 0.001). The three risk categories proved to be an independent risk factor in multivariate analyses. (4) Conclusion: The present study identifies three risk categories for the requirement of high flow nasal cannula, mechanical ventilation, ICU admission, and in-hospital mortality based on lymphopenia and inflammatory parameters.

Datos de la publicación

ISSN/ISSNe:
2077-0383, 2077-0383

Journal of clinical medicine  MDPI AG

Tipo:
Article
Páginas:
-
Factor de Impacto:
1,040 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 15

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • COVID-19; cytokine storm; prognosis; risk factors; mortality

Campos de estudio

Proyectos asociados

SUBREGISTRO PROSPECTIVO, MULTICÉNTRICO Y OBSERVACIONAL DE SEGURIDAD POSTAUTORIZACIÓN PARA CARACTERIZAR EL PERFIL DE SEGURIDAD A LARGO PLAZO DEL USO COMERCIAL DE ELIGLUSTAT (CERDELGA®) EN PACIENTES ADULTOS CON ENFERMEDAD DE GAUCHER.

Investigador Principal: PATRICIA CORRECHER MEDINA

OBS14099 . 2018

MEMORIA PARA EL ESTUDIO DE ESPLENOMEGALIA Y PACIENTES ESPLENECTOMIZADOS NO FILIADOS EN POBLACIÓN INFANTIL Y ADULTA.

Investigador Principal: ISIDRO VITORIA MIÑANA

PREDIGA . 2020

ENSAYO CLINICO ALEATORIZADO PARA EVALUAR LA EFICACIA DE DIFERENTES TRATAMIENTOS EN PACIENTES CON COVID19 QUE REQUIEREN HOSPITALIZACION.

Investigador Principal: MARTA MONTERO ALONSO

PANCOVID . 2020

Cita

Compartir