Portal de investigación
Prognostic Role of TAPSE to PASP Ratio in Patients Undergoing MitraClip Procedure
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Trejo-Velasco, B
- Estevez-Loureiro, R
- Carrasco-Chinchilla, F
- Fernandez-Vazquez, F
- Arzamendi, D
- Pan, MU
- Pascual, I
- Nombela-Franco, L
- Amat-Santos, IJ
- Freixa, X
- Hernandez-Antolin, RA
- Trillo-Nouche, R
- Ikazuriaga, LA
- Lopez-Minguez, JR
- Cervera, DS
- Sanchis, J
- Ruiz-Quevedo, V
- Urbano-Carrillo, C
- Becerra-Munoz, VM
- Benito-Gonzalez, T
- Li, CH
- Mesa, D
- Avanzas, P
- Armijo, G
- Serrador-Frutos, AM
- Sanchis, L
- Loban, CFG
- Cid-Alvarez, B
- Hernandez-Garcia, JM
- Garrote-Coloma, C
- Fernandez-Peregrina, E
- Romero, M
- Arguero, VL
- Cruz-Gonzalez, I
Grupos
Abstract
Background: Transcatheter mitral valve repair (TMVR) is an effective therapy for high-risk patients with severe mitral regurgitation (MR) but heart failure (HF) readmissions and death remain substantial on mid-term follow-up. Recently, right ventricular (RV) to pulmonary arterial (PA) coupling has emerged as a relevant prognostic predictor in HF. In this study, we aimed to assess the prognostic value of tricuspid annular plane systolic excursion (TAPSE) to PA systolic pressure (PASP) ratio as a non-invasive measure of RV-to-PA coupling in patients undergoing TMVR with MitraClip (Abbott, CA, USA). Methods: Multicentre registry including 228 consecutive patients that underwent successful TMVR with MitraClip. The sample was divided in two groups according to TAPSE/PASP median value: 0.35. The primary combined endpoint encompassed HF readmissions and all-cause mortality. Results: Mean age was 72.5 +/- 11.5 years and 154 (67.5%) patients were male. HF readmissions and all-cause mortality were more frequent in patients with TAPSE/PASP <= 0.35: Log-Rank 8.844, p = 0.003. On Cox regression, TAPSE/PASP emerged as a prognostic predictor of the primary combined endpoint, together with STS-Score. TAPSE/PASP was a better prognostic predictor than either TAPSE or PASP separately. Conclusions: TAPSE/PASP ratio appears as a novel prognostic predictor in patients undergoing MitraClip implantation that might improve risk stratification and candidate selection.
Datos de la publicación
- ISSN/ISSNe:
- 2077-0383, 2077-0383
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.3390/jcm10051006
- PubMed:
- 33801311
- Factor de Impacto:
- 1,040 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Journal of Clinical Medicine MDPI
Citas Recibidas en Web of Science: 40
Documentos
- No hay documentos
Filiaciones
Keywords
- MitraClip; mitral valve repair; mitral valve regurgitation; pulmonary hypertension; right ventricular to pulmonary arterial coupling; transthoracic echocardiography
Campos de Estudio
Cita
Trejo B,Estevez R,Carrasco F,Fernandez F,Arzamendi D,Pan MU,Pascual I,Nombela L,Amat IJ,Freixa X,Hernandez RA,Trillo R,Ikazuriaga LA,Lopez JR,Cervera DS,Sanchis J,DIEZ JL,Ruiz V,Urbano C,Becerra VM,Benito T,Li CH,Mesa D,Avanzas P,Armijo G,Serrador AM,Sanchis L,Loban CFG,Cid B,Hernandez JM,Garrote C,Fernandez E,Romero M,Arguero VL,Cruz I. Prognostic Role of TAPSE to PASP Ratio in Patients Undergoing MitraClip Procedure. J. Clin. Med. 2021. 10. (5):1006. IF:4,964. (2).