Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection

Fecha de publicación: 01/02/2021 Fecha Ahead of Print: 01/01/2021

Autores de IIS La Fe

Gabriela Alejandra Loscalzo

Autor
Alicia Martínez Varea

Autor
Vicente Jose Diago Almela

Autor

Participantes ajenos a IIS La Fe

Saccone, G
Sen, C
Di Mascio, D
Galindo, A
Grunebaum, A
Yoshimatsu, J
Stanojevic, M
Kurjak, A
Chervenak, F
Suarez, MJR
Gambacorti-Passerini, ZM
Baz, MDA
Galan, EVA
Lopez, YC
Luis, JAD
Hernandez, IC
Herraiz, I
Villalain, C
Venturella, R
Rizzo, G
Mappa, I
Gerosolima, G
Hellmeyer, L
Konigbauer, J
Ameli, G
Frusca, T
Volpe, N
Schera, GBL
Fieni, S
Esposito, E
Simonazzi, G
Di Donna, G
Youssef, A
Della Gatta, AN
Di Donna, MC
Chiantera, V
Buono, N
Sozzi, G
Greco, P
Morano, D
Bianchi, B
Marino, MGL
Laraud, F
Ramone, A
Cagnacci, A
Barra, F
Gustavino, C
Ferrero, S
Ghezzi, F
Cromi, A
Lagana, AS
Longo, VL
Stollagli, F
Sirico, A
Lanzone, A
Driul, L
Cecchini, F
Xodo, S
Rodriguez, B
Mercado-Olivares, F
Elkafrawi, D
Sisti, G
Esposito, R
Coviello, A
Cerbone, M
Morlando, M
Schiattarella, A
Colacurci, N
De Franciscis, P
Cataneo, I
Lenzi, M
Sandri, F
Buscemi, R
Gattei, G
della Sala, F
Valori, E
Rovellotti, MC
Done, E
Faron, G
Gucciardo, L
Esposito, V
Vena, F
Giancotti, A
Brunelli, R
Muzii, L
Nappi, L
Sorrentino, F
Liberati, M
Buca, D
Leombroni, M
Di Sebastiano, F
Franchi, M
Ianniciello, QC
Garzon, S
Petriglia, G
Borrello, L
Nieto-Calvache, AJ
Burgos-Luna, JM
Kadji, C
Carlin, A
Bevilacqua, E
Moucho, M
Pinto, PV
Figueiredo, R
Rosello, JM
Lopez, JSJ
Aykanat, Y
Cosma, S
Carosso, A
Benedetto, C
Bermejo, A
Feuerschuette, OHM
Uyaniklar, O
Ocakouglu, SR
Atak, Z
Gunduz, R
Haberal, ET
Froessler, B
Parange, A
Palm, P
Samardjiski, I
Taccaliti, C
Okuyan, E
Daskalakis, G
de Sa, RAM
Pittaro, A
Gonzalez-Duran, ML
Guisan, AC
Genc, SO
Zlatohlavkova, B
Piqueras, AL
Oliva, DE
Cil, AP
Api, O
Antsaklis, P
Ples, L
Kyvernitakis, I
Maul, H
Malan, M
Lila, A
Granese, R
Ercoli, A
Zoccali, G
Villasco, A
Biglia, N
Madalina, C
Costa, E
Daelemans, C
Pintiaux, A
Cueto, E
Hadar, E
Dollinger, S
Brzezinski-Sinai, NA
Huertas, E
Arango, P
Sanchez, A
Schvartzman, JA
Cojocaru, L
Turan, S
Turan, O
Di Dedda, MC
Molpeceres, RG
Zdjelar, S
Premru-Srsen, T
Kornhauser-Cerar, L
Druskovic, M
De Robertis, V
Stefanovic, V
Nupponen, I
Nelskyla, K
Khodjaeva, Z
Gorina, KA
Sukhikh, GT
Maruotti, GM
Visentin, S
Cosmi, E
Ferrari, J
Gatti, A
Luvero, D
Angioli, R
Puri, L
Palumbo, M
D'Urso, G
Colaleo, F
Rapisarda, AMC
Carbone, IF
Manzoli, L
Flacco, ME
Nazzaro, G
Locci, M
Guida, M
Sardo, AD
Panici, PB
Khalil, A
Berghella, V
Bifulco, G
Scambia, G
Zullo, F
D'Antonio, F
WAPM World Assoc Perinatal Med Wor

Abstract

Objectives To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251(27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. (C) 2020 International Society of Ultrasound in Obstetrics and Gynecology.