1. Inicio
  2. Publicaciones
  3. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection

Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

  • Gabriela Alejandra Loscalzo

    Autor

  • Alicia Martínez Varea

    Autor

  • Vicente Jose Diago Almela

    Autor

Participantes ajenos a IIS La Fe

  • Saccone, G
  • Sen, C
  • Di Mascio, D
  • Galindo, A
  • Grunebaum, A
  • Yoshimatsu, J
  • Stanojevic, M
  • Kurjak, A
  • Chervenak, F
  • Suarez, MJR
  • Gambacorti-Passerini, ZM
  • Baz, MDA
  • Galan, EVA
  • Lopez, YC
  • Luis, JAD
  • Hernandez, IC
  • Herraiz, I
  • Villalain, C
  • Venturella, R
  • Rizzo, G
  • Mappa, I
  • Gerosolima, G
  • Hellmeyer, L
  • Konigbauer, J
  • Ameli, G
  • Frusca, T
  • Volpe, N
  • Schera, GBL
  • Fieni, S
  • Esposito, E
  • Simonazzi, G
  • Di Donna, G
  • Youssef, A
  • Della Gatta, AN
  • Di Donna, MC
  • Chiantera, V
  • Buono, N
  • Sozzi, G
  • Greco, P
  • Morano, D
  • Bianchi, B
  • Marino, MGL
  • Laraud, F
  • Ramone, A
  • Cagnacci, A
  • Barra, F
  • Gustavino, C
  • Ferrero, S
  • Ghezzi, F
  • Cromi, A
  • Lagana, AS
  • Longo, VL
  • Stollagli, F
  • Sirico, A
  • Lanzone, A
  • Driul, L
  • Cecchini, F
  • Xodo, S
  • Rodriguez, B
  • Mercado-Olivares, F
  • Elkafrawi, D
  • Sisti, G
  • Esposito, R
  • Coviello, A
  • Cerbone, M
  • Morlando, M
  • Schiattarella, A
  • Colacurci, N
  • De Franciscis, P
  • Cataneo, I
  • Lenzi, M
  • Sandri, F
  • Buscemi, R
  • Gattei, G
  • della Sala, F
  • Valori, E
  • Rovellotti, MC
  • Done, E
  • Faron, G
  • Gucciardo, L
  • Esposito, V
  • Vena, F
  • Giancotti, A
  • Brunelli, R
  • Muzii, L
  • Nappi, L
  • Sorrentino, F
  • Liberati, M
  • Buca, D
  • Leombroni, M
  • Di Sebastiano, F
  • Franchi, M
  • Ianniciello, QC
  • Garzon, S
  • Petriglia, G
  • Borrello, L
  • Nieto-Calvache, AJ
  • Burgos-Luna, JM
  • Kadji, C
  • Carlin, A
  • Bevilacqua, E
  • Moucho, M
  • Pinto, PV
  • Figueiredo, R
  • Rosello, JM
  • Lopez, JSJ
  • Aykanat, Y
  • Cosma, S
  • Carosso, A
  • Benedetto, C
  • Bermejo, A
  • Feuerschuette, OHM
  • Uyaniklar, O
  • Ocakouglu, SR
  • Atak, Z
  • Gunduz, R
  • Haberal, ET
  • Froessler, B
  • Parange, A
  • Palm, P
  • Samardjiski, I
  • Taccaliti, C
  • Okuyan, E
  • Daskalakis, G
  • de Sa, RAM
  • Pittaro, A
  • Gonzalez-Duran, ML
  • Guisan, AC
  • Genc, SO
  • Zlatohlavkova, B
  • Piqueras, AL
  • Oliva, DE
  • Cil, AP
  • Api, O
  • Antsaklis, P
  • Ples, L
  • Kyvernitakis, I
  • Maul, H
  • Malan, M
  • Lila, A
  • Granese, R
  • Ercoli, A
  • Zoccali, G
  • Villasco, A
  • Biglia, N
  • Madalina, C
  • Costa, E
  • Daelemans, C
  • Pintiaux, A
  • Cueto, E
  • Hadar, E
  • Dollinger, S
  • Brzezinski-Sinai, NA
  • Huertas, E
  • Arango, P
  • Sanchez, A
  • Schvartzman, JA
  • Cojocaru, L
  • Turan, S
  • Turan, O
  • Di Dedda, MC
  • Molpeceres, RG
  • Zdjelar, S
  • Premru-Srsen, T
  • Kornhauser-Cerar, L
  • Druskovic, M
  • De Robertis, V
  • Stefanovic, V
  • Nupponen, I
  • Nelskyla, K
  • Khodjaeva, Z
  • Gorina, KA
  • Sukhikh, GT
  • Maruotti, GM
  • Visentin, S
  • Cosmi, E
  • Ferrari, J
  • Gatti, A
  • Luvero, D
  • Angioli, R
  • Puri, L
  • Palumbo, M
  • D'Urso, G
  • Colaleo, F
  • Rapisarda, AMC
  • Carbone, IF
  • Manzoli, L
  • Flacco, ME
  • Nazzaro, G
  • Locci, M
  • Guida, M
  • Sardo, AD
  • Panici, PB
  • Khalil, A
  • Berghella, V
  • Bifulco, G
  • Scambia, G
  • Zullo, F
  • D'Antonio, F
  • WAPM World Assoc Perinatal Med Wor

Abstract

Objectives To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251(27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. (C) 2020 International Society of Ultrasound in Obstetrics and Gynecology.

Datos de la publicación

ISSN/ISSNe:
0960-7692, 1469-0705

ULTRASOUND IN OBSTETRICS & GYNECOLOGY  WILEY-BLACKWELL

Tipo:
Article
Páginas:
232-241
PubMed:
32926494
Factor de Impacto:
4,443 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 134

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • coronavirus; COVID-19; infection; pregnancy; SARS-CoV-2

Campos de Estudio

Cita

Compartir