Portal de investigación
Malignancy following Heart Transplantation: Differences in Incidence and Prognosis between Sexes.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Minguito-Carazo C
- Gómez-Bueno M
- Barge-Caballero E
- González-Vílchez F
- Delgado-Jiménez JF
- Arizón-Del Prado JM
- Sousa-Casasnovas I
- Mirabet-Pérez S
- González-Costello J
- Sobrino-Márquez JM
- Pérez-Villa F
- Díaz-Molina B
- Juan-Aracil GR
- Blasco-Peiró T
- De la Fuente-Galán L
- Garrido-Bravo I
- García-Guereta L
- Camino M
- Albert-Brotons DC
- Muñiz J
- Crespo-Leiro MG
Grupos
Abstract
Male patients are at increased risk for developing malignancy post-heart transplantation (HT); however, real incidence and prognosis in both genders remains unknown. The aim of this study was to assess differences in incidence and mortality related to malignancy between genders in a large cohort of HT patients. Incidence and mortality rates were calculated for all tumors, skin cancers (SCs), lymphoma and non-skin solid cancers (NSSCs) as well as survival since first diagnosis of neoplasia. 5865 patients (81.6% male) were included. Total incidence rates for all tumors, SCs and NSSCs were lower in females (all tumors: 25.7 vs. 44.8 per 1000 person-years; Rate Ratio (RR) 0.68, (0.60-0.78), p<0.001). Mortality rates were also lower in females for all tumors (94.0 (77.3-114.3) vs. 129.6 (120.9-138.9) per 1000 person-years; RR 0.76, (0.62-0.94), p=0.01) and for NSSCs (125.0 (95.2-164.0) vs 234.7 (214.0-257.5) per 1000 person-years; RR 0.60 (0.44-0.80), p=0.001), albeit not for SCs or lymphoma. Female sex was associated to a better survival after diagnosis of malignancy (log-rank p test=0.0037; HR 0.74 (0.60-0.91), p=0.004). In conclusion, incidence of malignancies post-HT is higher in males than in females, especially for SCs and NSSCs. Prognosis after cancer diagnosis is also worse in males.
Datos de la publicación
- ISSN/ISSNe:
- 0934-0874, 1432-2277
- Tipo:
- Article
- Páginas:
- 882-893
- DOI:
- 10.1111/tri.13827
- PubMed:
- 33482021
- Factor de Impacto:
- 1,005 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
TRANSPLANT INTERNATIONAL WILEY
Citas Recibidas en Web of Science: 13
Documentos
- No hay documentos
Filiaciones
Keywords
- heart transplantation, malignancy, sexes
Campos de Estudio
Cita
Minguito C,Gómez M,ALMENAR L,Barge E,González F,Delgado JF,Arizón JM,Sousa I,Mirabet S,González J,Sobrino JM,Pérez F,Díaz B,Juan GR,Blasco T,De la Fuente L,Garrido I,García L,Camino M,Albert DC,Muñiz J,Crespo MG. Malignancy following Heart Transplantation: Differences in Incidence and Prognosis between Sexes. Transpl. Int. 2021. 34. (5):p. 882-893. IF:3,842. (1).