Portal de investigación
Extracellular Vesicles From Liver Progenitor Cells Downregulates Fibroblast Metabolic Activity and Increase the Expression of Immune-Response Related Molecules.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Royo F
- Azkargorta M
- Lavin JL
- Clos-Garcia M
- Cortazar AR
- Gonzalez-Lopez M
- Barcena L
- Del Portillo HA
- Yáñez-Mó M
- Borras FE
- Peinado H
- Guerrero I
- Váles-Gómez M
- Cereijo U
- Sardon T
- Aransay AM
- Elortza F
- Falcon-Perez JM
Grupos
Abstract
Extracellular vesicles (EVs) mediate cell-to-cell crosstalk whose content can induce changes in acceptor cells and their microenvironment. MLP29 cells are mouse liver progenitor cells that release EVs loaded with signaling cues that could affect cell fate. In the current work, we incubated 3T3-L1 mouse fibroblasts with MLP29-derived EVs, and then analyzed changes by proteomics and transcriptomics. Results showed a general downregulation of protein and transcript expression related to proliferative and metabolic routes dependent on TGF-beta. We also observed an increase in the ERBB2 interacting protein (ERBIN) and Cxcl2, together with an induction of ribosome biogenesis and interferon-related response molecules, suggesting the activation of immune system signaling.
Datos de la publicación
- ISSN/ISSNe:
- 2296-634X, 2296-634X
- Tipo:
- Article
- Páginas:
- 613583-613583
- PubMed:
- 33511119
- Factor de Impacto:
- 1,440 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Frontiers in Cell and Developmental Biology FRONTIERS MEDIA SA
Citas Recibidas en Web of Science: 4
Documentos
- No hay documentos
Filiaciones
Keywords
- MLP29, cell crosstalk, exosomes, extracellular vesicles (EVs), fibroblast, immune response