Sleep Apnoea Adverse Effects on Cancer: True, False, or Too Many Confounders?

Fecha de publicación: 20/11/2020 Fecha Ahead of Print: 20/11/2020

Autores de IIS La Fe

Miguel Ángel Martínez García

Autor

Participantes ajenos a IIS La Fe

Gozal D
Almendros I
Phipps AI
Campos-Rodriguez F
Farré R

Grupos

Neumología

Leader

Miguel Ángel Martínez García

Abstract

Obstructive sleep apnoea (OSA) is a prevalent disorder associated with increased cardiovascular, metabolic and neurocognitive morbidity. Recently, an increasing number of basic, clinical and epidemiological reports have suggested that OSA may also increase the risk of cancer, and adversely impact cancer progression and outcomes. This hypothesis is convincingly supported by biological evidence linking certain solid tumours and hypoxia, as well as by experimental studies involving cell and animal models testing the effects of intermittent hypoxia and sleep fragmentation that characterize OSA. However, the clinical and epidemiological studies do not conclusively confirm that OSA adversely affects cancer, even if they hold true for specific cancers such as melanoma. It is likely that the inconclusive studies reflect that they were not specifically designed to test the hypothesis or because of the heterogeneity of the relationship of OSA with different cancer types or even sub-types. This review critically focusses on the extant basic, clinical, and epidemiological evidence while formulating proposed directions on how the field may move forward.

Datos de la publicación

ISSN/ISSNe:: 1661-6596, 1661-6596
Tipo:: Review
Páginas:: -
DOI:: 10.3390/ijms21228779
PubMed:: 33233617
Factor de Impacto:: 1,455 SCImago ℠
Cuartil:: Q1 SCImago ℠

Documentos

No hay documentos

Métricas

Filiaciones

Gozal D:: Department of Child Health, The University of Missouri School of Medicine, Columbia, MO 65201, USA
Almendros I:: Unitat de Biofísica i Bioenginyeria, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, 08036 Barcelona, Spain

CIBER de Enfermedades Respiratorias, 28029 Madrid, Spain

Institut d'Investigacions Biomediques August Pi Sunyer, 08036 Barcelona, Spain
Phipps AI:: Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA

Epidemiology Program, Fred Hutchinson Research Cancer Research Center, Seattle, WA 98109, USA
Campos-Rodriguez F:: CIBER de Enfermedades Respiratorias, 28029 Madrid, Spain

Respiratory Department, Hospital Valme (Seville, Spain), Institute of Biomedicine of Seville (IBiS), 41014 Seville, Spain
Martínez-García MA:: Pneumology Department, Sleep-Disordered Breathing and Research Unit, Polytechnic and University La Fe Hospital, 46026 Valencia, Spain
Farré R:: Unitat de Biofísica i Bioenginyeria, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, 08036 Barcelona, Spain

CIBER de Enfermedades Respiratorias, 28029 Madrid, Spain

Institut d'Investigacions Biomediques August Pi Sunyer, 08036 Barcelona, Spain