Portal de investigación
Characterization of Locally Excited and Charge-Transfer States of the Anticancer Drug Lapatinib by Ultrafast Spectroscopy and Computational Studies.
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Lence E
- González-Bello C
- Navarrete-Miguel M
- Roca-Sanjuán D
Grupos
Abstract
Lapatinib (LAP) is an anticancer drug, which is metabolized to the N- and O-dealkylated products (N-LAP and O-LAP, respectively). In view of the photosensitizing potential of related drugs, a complete experimental and theoretical study has been performed on LAP, N-LAP and O-LAP, both in solution and upon complexation with human serum albumin (HSA). In organic solvents, coplanar locally excited (LE) emissive states are generated; they rapidly evolve towards twisted intramolecular charge-transfer (ICT) states. By contrast, within HSA only LE states are detected. Accordingly, femtosecond transient absorption reveals a very fast switching (ca. 2 ps) from LE (? max =550 nm) to ICT states (? max =480 nm) in solution, whereas within HSA the LE species become stabilized and live much longer (up to the ns scale). Interestingly, molecular dynamics simulation studies confirm that the coplanar orientation is preferred for LAP (or to a lesser extent N-LAP) within HSA, explaining the experimental results.
Datos de la publicación
- ISSN/ISSNe:
- 0947-6539, 1521-3765
- Tipo:
- Article
- Páginas:
- 15922-15930
- Factor de Impacto:
- 1,687 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
CHEMISTRY-A EUROPEAN JOURNAL WILEY-V C H VERLAG GMBH
Citas Recibidas en Web of Science: 11
Documentos
- No hay documentos
Filiaciones
Keywords
- anticancer drugs, femtosecond transient absorption, fluorescence, lapatinib, molecular dynamics simulations
Proyectos asociados
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PI16/01877 . INSTITUTO DE SALUD CARLOS III . 2017
Fotoalergia y fotocarcinogénesis debida a metabolitos y a fotoproductos de xenobióticos diana.
Investigador Principal: INMACULADA ANDREU ROS
ACIF/2018/153 . 2018
Asma, reacciones adversas y alergicas.
Investigador Principal: MIGUEL ÁNGEL MIRANDA ALONSO
RD16/0006/0030 . INSTITUTO DE SALUD CARLOS III . 2017
Cita
Vayá I,Andreu I,Lence E,González C,Consuelo M,Navarrete M,Roca D,Miranda MA. Characterization of Locally Excited and Charge-Transfer States of the Anticancer Drug Lapatinib by Ultrafast Spectroscopy and Computational Studies. Chem.-Eur. J. 2020. 26. (68):p. 15922-15930. IF:5,236. (2).