Portal de investigación
Prognostic value of cerebrospinal fluid biomarkers in mild cognitive impairment due to Alzheimer disease.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Grupos
Abstract
We performed a retrospective analysis of the patients assessed at our memory unit for whom Alzheimer disease (AD) cerebrospinal fluid biomarker results were available. We selected patients diagnosed with mild cognitive impairment due to AD (National Institute on Aging-Alzheimer's Association clinical criteria), confirmed neuropsychological deficit, a Global Deterioration Scale score of 3, and an abnormal profile of cerebrospinal fluid biomarkers. Of the 588 cases reviewed, 110 met the inclusion criteria. During follow-up, 50 cases (45.45%) progressed to dementia due to AD. Baseline levels of total and phosphorylated tau were higher in the group of patients that progressed to dementia than in those remaining with mild cognitive impairment. After adjusting for age, sex, history of hypertension, diabetes, and educational level, a 10% increase in total tau protein values was associated with a 7.60% increase in the risk of progression to dementia (hazard ratio: 2.22; 95% confidence interval, 1.28-3.84]; P = .004). Among patients with mild cognitive impairment due to AD and abnormal cerebrospinal fluid biomarker profiles, progressively higher concentrations of total or phosphorylated tau were associated with increased risk of progression to dementia.
Datos de la publicación
- ISSN/ISSNe:
- 0213-4853, 1578-1968
- Tipo:
- Article
- Páginas:
- 262-269
- PubMed:
- 33143865
- Enlace a otro recurso:
- www.scopus.com
- Factor de Impacto:
- 0,595 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
NEUROLOGIA ELSEVIER ESPANA SLU
Citas Recibidas en Web of Science: 3
Citas Recibidas en Scopus: 3
Documentos
- No hay documentos
Filiaciones
Keywords
- Alzheimer disease, Biomarcadores, Biomarkers, Demencia, Dementia, Deterioro cognitivo leve, Enfermedad de Alzheimer, Mild cognitive impairment, Prognosis, Pronóstico, Proteína tau, Tau protein
Campos de Estudio
Cita
LÓPEZ R,BAQUERO M,CUEVAS A,MARTÍN N,PASCUAL R,MORENO MJ,CAÑADA A,PEÑA C,FERRER I,ÁLVAREZ L,CHÁFER C. Prognostic value of cerebrospinal fluid biomarkers in mild cognitive impairment due to Alzheimer disease. Neurologia. 2020. 38. (4):p. 262-269. IF:3,109. (3).