Portal de investigación
Post-transplant cyclophosphamide for GVHD prophylaxis compared to ATG-based prophylaxis in unrelated donor transplantation.
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Bailén R
- Kwon M
- Pascual-Cascón MJ
- Ferrà C
- Gallardo-Morillo A
- García-Sola A
- Torrent A
- Jiménez-Lorenzo MJ
- Oarbeascoa G
- Dorado N
- Gómez-Centurión I
- Muñoz C
- Martínez-Laperche C
- Anguita J
- Buño I
- Díez-Martín JL
Grupos
Abstract
Post-transplant cyclophosphamide (PTCY) effectively prevents graft-versus-host disease after unmanipulated HLA-haploidentical HSCT. The use of PTCY in the unrelated donor HSCT setting is less explored. We conducted a retrospective study of 132 consecutive patients undergoing a matched or 9/10 mismatched unrelated donor HSCT in 4 centers in Spain, 60 with anti-thymocyte globulin (ATG)-based prophylaxis combined with MTX-CsA, and 72 using a PTCY-based regimen. Peripheral blood stem cells were used as graft in most patients (111 patients, 84%); mMUD donors were balanced between groups. Cumulative incidences of grades II-IV and III-IV acute GVHD at 100 days were lower in the PTCy group (46% vs. 67%, p = 0.008; 3% vs. 34%, p = 0.003), without statistically significant differences in the 2-year cumulative incidence of chronic moderate-severe GVHD. At 2 years, no significant differences were observed in overall survival, event-free survival, cumulative incidence of relapse, and non-relapse mortality. GVHD was the most frequent cause of NRM in the ATG group. No differences were observed between groups in the composite endpoint of GVHD-free and relapse-free survival. In this study, PTCy combined with additional immunosuppression after MUD/mMUD HSCT showed a reduction of aGVHD rate with safety results comparable to those obtained with the ATG-based prophylaxis.
Datos de la publicación
- ISSN/ISSNe:
- 0939-5555, 1432-0584
- Tipo:
- Article
- Páginas:
- 541-553
- PubMed:
- 33140137
- Factor de Impacto:
- 1,079 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
ANNALS OF HEMATOLOGY SPRINGER
Citas Recibidas en Web of Science: 35
Documentos
- No hay documentos
Filiaciones
Keywords
- GVHD prophylaxis, Post-transplant cyclophosphamide, Unrelated donor HSCT
Campos de Estudio
Cita
Bailén R,Kwon M,Pascual MJ,Ferrà C,SANZ J,Gallardo A,García A,Torrent A,Jiménez MJ,PIÑANA JL,MONTORO J,Oarbeascoa G,Dorado N,Gómez I,Muñoz C,Martínez C,Anguita J,Buño I,Díez JL. Post-transplant cyclophosphamide for GVHD prophylaxis compared to ATG-based prophylaxis in unrelated donor transplantation. Ann. Hematol. 2020. 100. (2):p. 541-553. IF:3,673. (2).