Portal de investigación
Idiopathic acute pancreatitis in patients with inflammatory bowel disease: A multicenter cohort study
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- de Paredes, AGG
- de Santiago, ER
- Rodriguez-Escaja, C
- Algaba, A
- Cameo, JI
- de la Pena, L
- Gomollon, F
- Van Domselaar, M
- Busta, R
- Garcia, AC
- Bermejo, F
- Gutierrez, A
- Guardiola, J
- Mesonero, F
- Riestra, S
- Albillos, A
- Lopez-Sanroman, A
Grupos
Abstract
Background: Idiopathic acute pancreatitis (LAP) in patients with inflammatory bowel disease (IBD) is not well characterized. Our purpose was to better understand this condition and its natural history. Methods: Retrospective cohort study conducted at nine Spanish IBD referral centers. Patients with IBD and a first episode of acute pancreatitis (AP) between 1998 and 2018 were included. Patients with a previous episode of AP or a diagnosis of chronic pancreatitis were excluded. LAP and non-LAP were compared by multivariate logistic regression and survival analysis. Results: We identified 185 patients with IBD (68.7% Crohn's disease) and a first episode of AP. Thirty-eight of those 185 (20.6%) fulfilled criteria for LAP. There were no severe cases of LAP. On multivariate analysis, AP before IBD diagnosis (21.1% vs. 3.4%, p = 0.04) and ulcerative colitis (52.6% vs. 23.1%, p = 0.002) were significantly more common in LAP. Further work-up was performed in 16/38 (42%) LAP patients, and a cause was identified in 6/16 (37.5%). Median time from AP to the end of follow-up was 6.3 years (3.1-10). Five-year risk of AP recurrence was significantly higher in LAP group (28% vs. 5.1%, log-rank p = 0.001), with a median time to first recurrence of 4.4 months (2.9-12.2). Conclusions: LAP represents the second cause of AP in patients with IBD. It is more frequent in ulcerative colitis, and presents a high risk of recurrence. Additional imaging work-up after a first episode of LAP in IBD patients is highly advisable, as it identifies a cause in more than one-third of cases. (C) 2020 LAP and EPC. Published by Elsevier B.V. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 1424-3903, 1424-3911
- Tipo:
- Article
- Páginas:
- 331-337
- PubMed:
- 32165149
- Factor de Impacto:
- 1,269 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Elsevier BV
Citas Recibidas en Web of Science: 9
Documentos
- No hay documentos
Filiaciones
Keywords
- Crohn disease; Inflammatory bowel diseases; Pancreatitis; Ulcerative colitis
Campos de Estudio
Cita
de Paredes A,de Santiago ER,Rodriguez C,IBORRA M,Algaba A,Cameo JI,de la Pena L,Gomollon F,Van M,Busta R,Garcia AC,DEL VAL A,Bermejo F,Gutierrez A,Guardiola J,Mesonero F,Riestra S,NOS P,Albillos A,Lopez A. Idiopathic acute pancreatitis in patients with inflammatory bowel disease: A multicenter cohort study. Pancreatology. 2020. 20. (3):p. 331-337. IF:3,996. (2).