Complex, not monosomal, karyotype is the cytogenetic marker of poorest prognosis in patients with primary myelodysplastic syndrome.

Autores de IIS La Fe

• Guillermo Sanz Santillana

  Autor

• Juan Bautista Montoro Gómez

  Autor

Participantes ajenos a IIS La Fe

• Valcárcel D
• Ademà V
• Solé F
• Ortega M
• Nomdedeu B
• Luño E
• Cañizo C
• de la Serna J
• Ardanaz M
• Marco V
• Collado R
• Grau J
• Mallo M
• Vallespí T

Abstract

Complex karyotype (CK) is the poorest risk factor in patients with myelodysplastic syndrome (MDS). It has recently been reported that monosomal karyotype (MK) worsens the prognosis of patients with CK. PATIENTS AND METHODS; We analyzed 1,054 adult patients with MDS with an abnormal karyotype from the Spanish Registry of MDS. The aim of the study was to describe the incidence, characteristics, and prognosis of MK; the main end points were overall survival (OS) and leukemia-free survival.