Portal de investigación
Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Poyatos-Racionero, E
- Gonzalez-Alvarez, I
- Gonzalez-Alvarez, M
- Bernardos, A
Grupos
Abstract
In recent decades, the versatility of mesoporous silica particles and their relevance to develop controlled release systems have been demonstrated. Within them, gated materials able to modulate payload delivery represent great advantages. However, the role played by the porous matrix in this kind of systems is scarce. In this work, different mesoporous silica materials (MCM-41, MCM-48, SBA-15 and UVM-7) are functionalized with oleic acid as a molecular gate. All systems are fully characterized and their ability to confine the entrapped cargo and release it in the presence of bile salts is validated with release assays and in vitro digestion experiments. The cargo release profile of each synthesized support is studied, paying attention to the inorganic scaffold. Obtained release profiles fit to Korsmeyer-Peppas model, which explains the differences among the studied supports. Based on the results, UVM-7 material was the most appropriate system for duodenal delivery and was tested in an in vivo model of the Wistar rat. Payload confinement and its complete release after gastric emptying is achieved, establishing the possible use of mesoporous silica particles as protection and direct release agents into the duodenum and, hence, demonstrating that these systems could serve as an alternative to the administration methods employed until now.
Datos de la publicación
- ISSN/ISSNe:
- 2079-4991, 2079-4991
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.3390/nano10071290
- Factor de Impacto:
- 0,919 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
NANOMATERIALS Multidisciplinary Digital Publishing Institute (MDPI)
Citas Recibidas en Web of Science: 7
Documentos
- No hay documentos
Filiaciones
Keywords
- mesoporous silica; oleic acid; molecular gate; MCM-41; MCM-48; SBA-15; UVM-7; controlled release; kinetic modelling; gastrointestinal delivery
Proyectos asociados
NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMÉDICO
Investigador Principal: JUAN BAUTISTA SALOM SANVALERO
MAT2015-64139-C4-1-R . MINISTERIO DE ECONOMIA Y COMPETITIVIDAD . 2016
PROGRAMA TÉCNICO DE APOYO. MODALIDAD INFRAESTRUCTURA.
Investigador Principal: RAMÓN MARTÍNEZ MÁÑEZ
PTA2016-12603-1 . MINISTERIO DE ECONOMIA Y COMPETITIVIDAD . 2018
Contrato I-PFIS: Predoctorales de formación en investigación en salud.
Investigador Principal: RAMÓN MARTÍNEZ MÁÑEZ
IFI17/00039 . INSTITUTO DE SALUD CARLOS III . 2018
Contrato Post FSE (Rio Hortega)
Investigador Principal: RAMÓN MARTÍNEZ MÁÑEZ
CM18/00078 . INSTITUTO DE SALUD CARLOS III . 2019
PLATAFORMA PARA LA DETECCIÓN DE PATÓGENOS BASADA EN MATERIALES CON PUERTAS MOLECULARES (PATH-GATE).
Investigador Principal: RAMÓN MARTÍNEZ MÁÑEZ
DTS18/00090 . INSTITUTO DE SALUD CARLOS III . 2019
Cita
Poyatos E,Gonzalez I,Gonzalez M,Martinez R,Marcos MD,Bernardos A,Aznar E. Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery. Nanomaterials (Basel). 2020. 10. (7):1290. IF:5,076. (1).