Portal de investigación
Impact of HIV on the survival of hepatocellular carcinoma in hepatitis C virus-infected patients
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Merchante, N
- Rodriguez-Fernandez, M
- Figueruela, B
- Rodriguez-Arrondo, F
- Revollo, B
- Ibarra, S
- Tellez, F
- Merino, E
- Galindo, MJ
- Rivero-Juarez, A
- de Los Santos, I
- Delgado-Fernandez, M
- Garcia-Deltoro, M
- Vera-Mendez, FJ
- Garcia, MA
- Aguirrebengoa, K
- Portu, J
- Rios-Villegas, MJ
- Villalobos, M
- Aleman-Valls, MR
- Minguez, C
- Galera, C
- Macias, J
- Pineda, JA
Grupos
Abstract
Background: Previous studies have suggested that hepatocellular carcinoma (HCC) has an aggressive presentation and a shorter survival in people with HIV (PWH). This could be due to later diagnosis or lower rates of HCC treatment, and not to HIV infection itself. Aim: : To assess the impact of HIV on HCC survival in hepatitis C virus (HCV)-infected patients. Methods: Multicenter cohort study (1999-2018) of 342 and 135 HCC cases diagnosed in HIV/HCV-infected and HCV-monoinfected patients. Survival after HCC diagnosis and its predictors were assessed. Results: HCC was at Barcelona-Clinic Liver-Cancer (BCLC) stage 0/A in 114 (33%) HIV/HCV-coinfected and in 76 (56%) HCV-monoinfected individuals (P < 0.001). Of them, 97 (85%) and 50 (68%) underwent curative therapies (P = 0.001). After a median (Q1-Q3) follow-up of 11 (3-31) months, 334 (70%) patients died. Overall 1 and 3-year survival was 50 and 31% in PWH and 69 and 34% in those without HIV (P = 0.16). Among those diagnosed at BCLC stage 0/A, 1 and 3-year survival was 94 and 66% in PWH whereas it was 90 and 54% in HIV-negative patients (P = 0.006). Independent predictors of mortality were age, BCLC stage and alpha-fetoprotein levels. HIV infection was not independently associated with mortality [adjusted hazard ratio (AHR) 1.57; 95% confidence interval: 0.88-2.78;P = 0.12]. Conclusion: HIV coinfection has no impact on the survival after the diagnosis of HCC in HCV-infected patients. Although overall mortality is higher in HIV/HCV-coinfected patients, this seem to be related with lower rates of early diagnosis HCC in HIV-infected patients and not with HIV infection itself or a lower access to HCC therapy.
Datos de la publicación
- ISSN/ISSNe:
- 0269-9370, 1473-5571
- Tipo:
- Article
- Páginas:
- 1497-1507
- PubMed:
- 32675563
- Factor de Impacto:
- 2,195 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
AIDS LIPPINCOTT WILLIAMS & WILKINS
Citas Recibidas en Web of Science: 9
Documentos
- No hay documentos
Filiaciones
Keywords
- cirrhosis; hepatitis C virus; hepatocellular carcinoma; HIV; liver cancer