Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation

Autores de IIS La Fe

• Natividad Sebastiá Fabregat

  Autor

• Alegría Montoro Pastor

  Autor

• Antonio José Cañada Martinez

  Autor

• David Hervás Marín

  Autor

• Pilar Gras Miralles

  Autor

• Juan Ignacio Villaescusa Blanca

  Autor

• 

  Luis Martí Bonmatí

  Autor

• Bianca Tabita Muresan

  Autor

• José Miguel Soriano Del Castillo

  Autor

• Juan Manuel Campayo Esteban

  Autor

• Joaquín Andani Cervera

  Autor

• Oscar Alonso Nacher

  Autor

• Regina Rodrigo Nicolás

  Autor

Participantes ajenos a IIS La Fe

• Olivares-Gonzalez, L
• Barquinero, JF

Grupos

• Investigacion Biomédica en Imagen (GIBI 2-30)

• Unidad Mixta de Investigación en Endocrinología, Nutrición y Dietética clínica

Abstract

The purpose of this study was to evaluate the relationship between blood redox status, dose and antioxidant dietary intake of different hospital staff groups exposed to low doses of ionizing radiation (LDIR) (Interventional Radiology and Cardiology, Radiation Oncology, and Nuclear Medicine) and non-exposed. Personal dose equivalent (from last year and cumulative), plasma antioxidant markers (total antioxidant capacity, extracellular superoxide dismutase activity, and glutathione/oxidized glutathione ratio), oxidative stress markers (nitrites and nitrates, and lipid peroxidation) and dietary intake (antioxidant capacity using ORAC values) were collected and analyzed from 28 non-exposed healthcare workers and 42 healthcare workers exposed to LDIR. Hospital staff exposed to LDIR presented a redox imbalance in blood that seems to correlate with dose. Workers from the Nuclear Medicine Unit were the most affected group with the lowest value of plasma antioxidant response and the highest value of plasma thiobarbituric acid reactive substances, TBARS (indicator of lipid peroxidation) of all four groups. Cumulative personal dose equivalent positively correlated with nitrites and negatively correlated with total antioxidant capacity in blood. The diet of healthcare workers from Nuclear Medicine Unit had higher ORAC values than the diet of non-exposed. Therefore, occupational exposure to LDIR, especially for the Nuclear Medicine Unit, seems to produce an imbalanced redox status in blood that would correlate with cumulative personal dose equivalent.

Keywords

• antioxidant-oxidant status; ionizing radiation; occupational exposure; oxygen radical absorbance capacity (ORAC); personal dose equivalent