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From genetics to epigenetics to unravel the etiology of adolescent idiopathic scoliosis

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Perez-Machado, G
  • Berenguer-Pascual, E
  • Garcia-Lopez, E
  • Garzon, MJ
  • Mena-Molla, S
  • Pallardo, FV
  • Vina, JR
  • Garcia-Gimenez, JL

Abstract

Scoliosis is defined as the three-dimensional (3D) structural deformity of the spine with a radiological lateral Cobb angle (a measure of spinal curvature) of >= 10 degrees that can be caused by congenital, developmental or de- generative problems. However, those cases whose etiology is still unknown, and affect healthy children and adolescents during growth, are the commonest form of spinal deformity, known as adolescent idiopathic scoliosis (AIS). In AIS management, early diagnosis and the accurate prediction of curve progression are most important because they can decrease negative long-term effects of AIS treatment, such as unnecessary bracing, frequent exposure to radiation, as well as saving the high costs of AIS treatment. Despite efforts made to identify a method or technique capable of predicting AIS progression, this challenge still remains unresolved. Genetics and epigenetics, and the application of machine learning and artificial intelligence technologies, open up new avenues to not only clarify AIS etiology, but to also identify potential biomarkers that can substantially improve the clinical management of these patients. This review presents the most relevant biomarkers to help explain the etiopathogenesis of AIS and provide new potential biomarkers to be validated in large clinical trials so they can be finally implemented into clinical settings.

Datos de la publicación

ISSN/ISSNe:
8756-3282, 1873-2763

Bone  Elsevier BV

Tipo:
Review
Páginas:
115563-115563
Factor de Impacto:
1,346 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 21

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Keywords

  • Adolescent idiopathic scoliosis; Biomarkers; GWAS; Epigenetics; DNA methylation; Noncoding RNAs

Proyectos asociados

EFECTIVIDAD BIOMECÁNICA DE LOS TORNILLOS TRANSDISCALES EN LA ESPONDILOLISTESIS L5-S1 FRENTE A TORNILLOS TRANSPEDICULARES Y CAJAS.

Investigador Principal: ISABEL COLLADOS MAESTRE

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Investigador Principal: JUAN BAUTISTA MOLLAR MASERES

B3451002 . FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2015

CLINICAL PERFORMANCE OF THE SCOLIPRO® KIT FOR THE PROGNOSIS OF ADOLESCENT IDIOPATHIC SCOLIOSIS. DISCOVERY OF PREDICTIVE MARKERS OF BRACE TREATMENT RESPONSE.

Investigador Principal: TERESA BAS HERMIDA

E.26 . 2020

ESTUDIO OBSERVACIONAL AMBISPECTIVO PARA LA VALIDACIÓN CLÍNICA A PEQUEÑA ESCALA DE LA FUNCIÓN PRONÓSTICO DEL TEST SCOLIPRO® A PARTIR DE PACIENTES DIAGNOSTICADOS DE ESCOLIOSIS IDIOPÁTICA ADOLESCENTE (EIA), CON RECOGIDA DE DATOS CLÍNICOS DESDE EL MOMENTO DE DIAGNÓSTICO.

Investigador Principal: TERESA BAS HERMIDA

E.01 . 2018

ESTUDIO DE PRUEBA DE CONCEPTO, ALEATORIZADO, DOBLE CIEGO, CONTROLADO CON PLACEBO PARA EVALUAR LA SEGURIDAD Y LA EFICACIA DEL ELEZANUMAB EN LA LESIÓN AGUDA TRAUMÁTICA DE MÉDULA ESPINAL CERVICAL.

Investigador Principal: TERESA BAS HERMIDA

M16-077 . 2020

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