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Targeting inflammasome by the inhibition of caspase-1 activity using capped mesoporous silica nanoparticles.

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • García-Fernández A
  • Costero AM
  • Orzáez M

Grupos

Abstract

Acute inflammation is a protective response of the body to harmful stimuli, such as pathogens or damaged cells. However, dysregulated inflammation can cause secondary damage and could thus contribute to the pathophysiology of many diseases. Inflammasomes, the macromolecular complexes responsible for caspase-1 activation, have emerged as key regulators of immune and inflammatory responses. Therefore, modulation of inflammasome activity has become an important therapeutic approach. Here we describe the design of a smart nanodevice that takes advantage of the passive targeting of nanoparticles to macrophages and enhances the therapeutic effect of caspase-1 inhibitor VX-765 in vivo. The functional hybrid systems consisted of MCM-41-based nanoparticles loaded with anti-inflammatory drug VX-765 (S2-P) and capped with poly-L-lysine, which acts as a molecular gate. S2-P activity has been evaluated in cellular and in vivo models of inflammation. The results indicated the potential advantage of using nanodevices to treat inflammatory diseases.

Datos de la publicación

ISSN/ISSNe:
0168-3659, 1873-4995

JOURNAL OF CONTROLLED RELEASE  ELSEVIER

Tipo:
Article
Páginas:
60-70
PubMed:
28069553
Factor de Impacto:
2,684 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 31

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Keywords

  • Gated mesoporous silica nanoparticles, VX-765, air pouch mouse model, controlled release, inflammasome, macrophages

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