Portal de investigación
Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I-NBOMe.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Garrido E
- Lozano-Torres B
- Parra M
- Gaviña P
Grupos
Abstract
This work reports the synthesis, characterization, and sensing behavior of a hybrid nanodevice for the detection of the potent abuse drug 25I-NBOMe. The system is based on mesoporous silica nanoparticles, loaded with a fluorescent dye, functionalized with a serotonin derivative and capped with the 5-HT 2A receptor antibody. In the presence of 25I-NBOMe the capping antibody is displaced, leading to pore opening and rhodamine B release. This delivery was ascribed to 5-HT 2A receptor antibody detachment from the surface due to its stronger coordination with 25I-NBOMe present in the solution. The prepared nanodevice allowed the sensitive (limit of detection of 0.6 µm) and selective recognition of the 25I-NBOMe drug (cocaine, heroin, mescaline, lysergic acid diethylamide, MDMA, and morphine were unable to induce pore opening and rhodamine B release). This nanodevice acts as a highly sensitive and selective fluorometric probe for the 25I-NBOMe illicit drug in artificial saliva and in sweets.
Datos de la publicación
- ISSN/ISSNe:
- 0947-6539, 1521-3765
- Tipo:
- Article
- Páginas:
- 2813-2816
- Factor de Impacto:
- 1,687 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
CHEMISTRY-A EUROPEAN JOURNAL WILEY-V C H VERLAG GMBH
Citas Recibidas en Web of Science: 9
Documentos
- No hay documentos
Filiaciones
Keywords
- 25I-NBOMe, agonist 5-HT2A serotonin receptor, hallucinogenic drugs, mesoporous silica nanoparticles, sensors
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Cita
Garrido E,Alfonso M,Díaz de Greñu B,Lozano B,Parra M,Gaviña P,Marcos MD,Martínez R,Sancenón F. Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I-NBOMe. Chem.-Eur. J. 2020. 26. (13):p. 2813-2816. IF:5,236. (2).