Genome-wide profiling of non-smoking-related lung cancer cells reveals common RB1 rearrangements associated with histopathologic transformation in EGFR-mutant tumors.

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Pros E
  • Saigi M
  • Alameda D
  • Gomez-Mariano G
  • Martinez-Delgado B
  • Alburquerque-Bejar JJ
  • Carretero J
  • Tonda R
  • Esteve-Codina A
  • Catala I
  • Palmero R
  • Jove M
  • Lazaro C
  • Patiño-Garcia A
  • Gil-Bazo I
  • Verdura S
  • Teulé A
  • Torres-Lanzas J
  • Sidransky D
  • Reguart N
  • Pio R
  • Nadal E
  • Felip E
  • Montuenga LM
  • Sanchez-Cespedes M

Grupos

Abstract

The etiology and the molecular basis of lung adenocarcinomas (LuADs) in nonsmokers are currently unknown. Furthermore, the scarcity of available primary cultures continues to hamper our biological understanding of non-smoking-related lung adenocarcinomas (NSK-LuADs).

Datos de la publicación

ISSN/ISSNe:
0923-7534, 1569-8041

ANNALS OF ONCOLOGY  ELSEVIER

Tipo:
Article
Páginas:
274-282
PubMed:
31959344
Factor de Impacto:
7,954 SCImago
Cuartil:
Q1 SCImago

Citas Recibidas en Web of Science: 46

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Keywords

  • EGFR, RB1, lung adenocarcinoma, nonsmokers, tyrosine kinase inhibitors, whole-exome sequencing

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