Oxygen in the neonatal period: Oxidative stress, oxygen load and epigenetic changes.

Autores de IIS La Fe

• Sheila Lorente Pozo

  Autor

• Anna Parra Llorca

  Autor

• Inmaculada Lara Cantón

  Autor

• Álvaro José Solaz García

  Autor

• Máximo Vento Torres

  Autor

Participantes ajenos a IIS La Fe

• García-Jiménez JL
• Pallardó FV

Grupos

• Perinatología

Abstract

Preterm infants frequently require positive pressure ventilation and oxygen supplementation in the first minutes after birth. It has been shown that the amount of oxygen provided during stabilization, the oxygen load, if excessive may cause hyperoxia, and oxidative damage to DNA. Epidemiologic studies have associated supplementation with pure oxygen in the first minutes after birth with childhood cancer. Recent studies have shown that the amount of oxygen supplemented to preterm infants after birth modifies the epigenome. Of note, the degree of DNA hyper-or hypomethylation correlates with the oxygen load provided upon stabilization. If these epigenetic modifications would persist, oxygen supplied in the first minutes after birth could have long term consequences. Further studies with a robust power calculation and long-term follow up are needed to bear out the long-term consequences of oxygen supplementation during postnatal stabilization of preterm infants.

Keywords

• Epigenetics, Oxidative stress, Oxygen, Prematurity