Development and validation of two food frequency questionnaires to assess gluten intake in children up to 36 months of age

Autores de IIS La Fe

• Paula Crespo Escobar

  Autor

• Joaquin Calvo Lerma

  Autor

• David Hervás Marín

  Autor

• Ester Donat Aliaga

  Autor

• Etna Masip Simó

  Autor

• Begoña Polo Miquel

  Autor

• 

  Carmen Ribes Koninckx

  Autor

Grupos

• Enfermedad celíaca e Inmunopatología digestiva

Abstract

Background and objective: precise information on gluten consumption is crucial for specifically studying the impact of gluten introduction and gluten intake in celiac disease development. Our aim was to develop and validate tools (food frequency questionnaires, FFQs) for the assessment of gluten consumption in Spanish children aged 7-36 months. Methods: a total of 342 children, who attended primary healthcare centers for routine health surveys or La Fe Hospital for minor health problems as well as healthy children (recruited in nurseries and primary schools) participated in this survey. We have developed two different FFQs (one for 7-12 months and other for 13-36 months). For validation, results from two FFQs were compared with results of 2-day food records and also with the gold standard 7-day records. The mean gluten intake obtained by the 2DR vs. FFQ and the 7DR vs. FFQ, were compared using the Bland Altman plot method and also Lin's concordance correlation coefficient. Results: we found a good agreement between our FFQs and the 2DR and 7DR according to the results of both the Bland-Altman plots and Lin's concordance correlation coefficient. Conclusions: our two new FFQs are therefore the only validated questionnaires available to determine gluten consumption in Spanish children. They are user-friendly and offer excellent instruments to assess gluten intake in children up to 36 months of age.

Keywords

• Celiac disease; Gluten; Food frequency questionnaire; Spanish; Children