Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia.

Autores de IIS La Fe

• Ana Belen Valencia Martinez

  Autor

• José Vicente Cervera Zamora

  Autor

• Esperanza Such Taboada

  Autor

• Eva Barragán González

  Autor

• Pascual Bolufer Gilabert

  Autor

• Oscar Fuster Lluch

  Autor

• Rosa Collado Escuder

  Autor

• Joaquina Martinez Bonete

  Autor

• 

  Miguel Ángel Sanz Alonso

  Autor

Grupos

• Hematología y Hemoterapia

  

  Investigador Principal

  Javier De La Rubia Comos

• Investigación Clínica y Traslacional en Cáncer

  

  Leader

  José Gómez Codina

Abstract

The Philadelphia (Ph(1)) chromosome arising from the reciprocal t(9;22) translocation is found in more than 90% of chronic myeloid leukemia (CML) patients and results in the formation of the chimeric fusion gene BCR-ABL. However, a small proportion of patients with CML have simple or complex variants of this translocation, involving various breakpoints in addition to 9q34 and 22q11. We report five CML cases carrying variant Ph translocations involving both chromosomes 9 and 22 as well as chromosomes 3, 5, 7, 8, or 10. G-banding showed a reciprocal three-way translocation involving 3q21, 5q31, 7q32, 8q24, and 10q22 bands. BCR-ABL fusion signal on der(22) was found in all of the cases by FISH.