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Sacubitril/valsartan-treated patients with exacerbated acute heart failure: approaches to care in the emergency department and on the ward

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Miro, O
  • Martin-Sanchez, FJ
  • Jacob, J
  • Herrero-Puente, P
  • Gil, V
  • Llorens, P
  • Fuentes, M
  • Alonso, H
  • Perez-Llantada, E
  • Garcia, GL
  • Cadenas, MS
  • Escoda, R
  • Xipell, C
  • Sanchez, C
  • Jerez, A
  • Pavon, J
  • Noval, A
  • Torres, JM
  • Lopez-Grima, ML
  • Valero, A
  • Juan, MA
  • Aguirre, A
  • Pedragosa, MA
  • Maso, SM
  • Alonso, MI
  • Ruiz, F
  • Franco, JM
  • Mecina, AB
  • Tost, J
  • Berenguer, M
  • Donea, R
  • Ramon, SS
  • Rodriguez, VC
  • Pinera, P
  • Nicolas, JAS
  • Garate, RT
  • Alquezar-Arbe, A
  • Rizzi, MA
  • Herrera, S
  • Roset, A
  • Cabello, I
  • Haro, A
  • Richard, F
  • Perez, JMA
  • Diez, MPL
  • Puente, PH
  • Alvarez, JV
  • Garcia, BP
  • Garcia, MG
  • Gonzalez, MS
  • Javaloyes, P
  • Marquina, V
  • Jimenez, I
  • Hernandez, N
  • Brouzet, B
  • Espinosa, B
  • Gil, A
  • Andueza, JA
  • Romero, R
  • Ruiz, M
  • Calvache, R
  • Serralta, MTL
  • Jave, LEC
  • Arriaga, BA
  • Bergua, BS
  • Mojarro, EM
  • Jimenez, BSA
  • Becquer, LT
  • Burillo, G
  • Garcia, LL
  • La-Salle, GC
  • Urbano, CA
  • Soto, ABG
  • Padial, ED
  • Ferrer, ES
  • Garrido, JM
  • Lucas-Imbernon, FJ
  • Gaya, R
  • Bibiano, C
  • Mir, M
  • Rodriguez, B
  • Carballo, JL
  • Rodriguez-Adrada, E
  • Miranda, BR
  • Martin, MV
  • Casanova, PC
  • Alvaos, JE

Grupos

Abstract

Objectives. To describe the pattern of care usually given to patients with acute heart failure (AHF) who are taking sacubitril/valsartan (SV) and to explore the effects of care characteristics on clinical outcomes. Methods. Exploratory study of AHF cases in patients taking SV who were included in the register for the Epidemiology of Acute Heart Failure in Emergency Departments during the sixth period of data collection (EAHFE-6). We extracted baseline and episode variables and information related to SV treatment. We also analyzed associations between the discontinuation of SV therapy and adverse events within 180 days (all-cause mortality) and after discharge (emergency revisits, admission for AHF, death from any cause, or a composite event). Results. Fifty patients on SV were included. The median time on SV therapy was 81 days (interquartile range, 43-284 days). SV was discontinued in 19 cases (38%; 5 in the emergency department and 14 on the ward). Sixteen records specified the reason for discontinuing SV: renal insufficiency, 4 cases; arterial hypotension, 3; weakness/dizziness, 3; and exacerbated AHF, 3. SV discontinuation was associated with older age, absence of treatment with a betablocker, and hyperkalemia. The EAHFE-6 cases did not reveal significant differences related to SV discontinuation with respect to the rates of adverse events within 180 days or on discharge after the index event. Conclusions. Long-term SV therapy is discontinued in over a third of patients who present with exacerbated AHF even though no association with clinical outcomes could be identified.

Datos de la publicación

ISSN/ISSNe:
1137-6821, 2386-5857

EMERGENCIAS  SANIDAD EDICIONES

Tipo:
Article
Páginas:
407-412
DOI:
PubMed:
31777213
Factor de Impacto:
0,373 SCImago ℠
Cuartil:
Q2 SCImago ℠

Citas Recibidas en Web of Science: 4

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Keywords

  • Acute heart failure; Sacubitril/valsartan; Mortality; Revisiting; Emergency department, hospital

Proyectos y Estudios Clínicos

PRAGMATIC, CONTROLLED, INTERNATIONAL STUDY CONDUCTED IN SEVERAL CENTRES ON THE SAFETY AND THERAPEUTIC EFFECT OF A HYDROXYLETHYL-STARCH (HES) SOLUTION VERSUS AN ELECTROLYTE SOLUTION IN TRAUMA PATIENTS.

Investigador Principal: ÓSCAR DÍAZ CAMBRONERO

HC-G-H-1505 . 2018

EFECTO DE V0251 EN EL VÉRTIGO AGUDO. ESTUDIO ALEATORIZADO, DOBLE CIEGO Y CONTROLADO CON PLACEBO.

Investigador Principal: HERMINIO PÉREZ GARRIGUES

V00251IV2024A

PERFIL DE RIESGO DE LOS PACIENTES CON ETV EN HOSPITALES ESPAÑOLES ATENDIDOS EN LOS SERVICIOS DE URGENCIAS E IMPACTO ASISTENCIAL: REGISTRO ESPHERIA.

Investigador Principal: MARÍA JOSÉ PÉREZ DURÁ

ESPHERIA

PLANIFICACIÓN DEL ALTA DESDE URGENCIAS PARA REDUCIR REINGRESOS A 30 DÍAS EN MAYORES FRÁGILES CON INSUFICIENCIA CARDÍACA AGUDA: ENSAYO CLÍNICO ALEATORIZADO POR CONGLOMERADOS PAREADO.

Investigador Principal: CARMEN GARGALLO MAICAS

DEED FRAIL-AHF . 2019

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