Biomonitoring of non-persistent pesticides in urine from lactating mothers: Exposure and risk assessment.

Fecha de publicación: 10/01/2020 Fecha Ahead of Print: 10/09/2019

Autores de IIS La Fe

Marta Isabel Roca Marugán

Autor
Máximo Vento Torres

Autor
María Cernada Badía

Autor
Vicent Yusa Pelecha

Autor

Participantes ajenos a IIS La Fe

Fernández SF
Pardo O
Adam-Cervera I
Montesinos L
Corpas-Burgos F
Pastor A

Grupos

Perinatología

Leader

Máximo Vento Torres

Abstract

The aim of the present study was to assess the exposure to pesticides in urine from Spanish lactating mothers (n?=?116). Six nonspecific (dialkyl phosphates) and 20 specific metabolites of organophosphate pesticides (OPs), herbicides and pyrethroids were analyzed. The most frequently detected biomarkers were diethyl phosphate, p-nitrophenol, 3,5,6-trichloro-2-pyridinol and 3-phenoxybenzoic acid, whose geometric means were 1.9?ngmL -1 , 0.8?ngmL -1 , 1.5?ngmL -1 and 1.4?ngmL -1 , respectively. Herbicide metabolites were the least frequently detected biomarkers with detection frequencies between 0% (2,4,5-Trichlorophenoxyacetic acid) and 22% (2,4-Dichlorophenoxyacetic acid). Multiple regression analyses showed that the closeness to a farming activity, the place of residence and the presence of garden/plants at home were some of the most important contributors to urinary levels of pesticide metabolites. Estimated daily intake (EDI), hazard quotient (HQ) and hazard index (HI) were obtained in order to interpret urinary levels of the most frequently detected pesticide metabolites in a risk assessment context. The highest EDIs were obtained for chlorpyrifos (0.40-1.14?gkg?bw -1 day -1 ) and deltamethrin (0.34-4.73?gkg?bw - 1 day -1 ). The calculated HQ for chlorpyrifos, dimethoate, parathion and deltamethrin ranged from 0.01 to 0.47, and HI for OPs ranged from 0.09 to 0.33 showing that apparently there were low health risks due to the exposure to these pesticides in this group of Spanish breastfeeding women.

Datos de la publicación

ISSN/ISSNe:: 0048-9697, 1879-1026
Tipo:: Article
Páginas:: 134385-134385
DOI:: 10.1016/j.scitotenv.2019.134385
Factor de Impacto:: 1,795 SCImago ℠
Cuartil:: Q1 SCImago ℠

Documentos

No hay documentos

Métricas

Filiaciones

Fernández SF:: Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain

Public Health Laboratory of Valencia, Av. Cataluña, 21, 46020 Valencia, Spain
Pardo O:: Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain

Public Health Laboratory of Valencia, Av. Cataluña, 21, 46020 Valencia, Spain
Adam-Cervera I:: Institute of Materials Science of the University of Valencia (ICMUV), University of Valencia, Catedrático José Beltrán, 2, 46980 Paterna, Spain
Montesinos L:: Public Health Laboratory of Valencia, Av. Cataluña, 21, 46020 Valencia, Spain
Corpas-Burgos F:: Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Roca, M:: Instituto de Investigación. Analytical Unit, Health Research Institute La Fe, Av. Abril Martorell, 106, 46026 Valencia, Spain
Pastor A:: Department of Analytical Chemistry, University of Valencia, Doctor Moliner 50, 46100, Burjassot, Spain
Vento M:: Instituto de Investigación. Neonatal Research Group, Health Research Institute La Fe, Av. Abril Martorell, 106, 46026 Valencia, Spain
Cernada M:: Instituto de Investigación. Neonatal Research Group, Health Research Institute La Fe, Av. Abril Martorell, 106, 46026 Valencia, Spain
Yusà V:: Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain

Public Health Laboratory of Valencia, Av. Cataluña, 21, 46020 Valencia, Spain

Instituto de Investigación. Analytical Unit, Health Research Institute La Fe, Av. Abril Martorell, 106, 46026 Valencia, Spain