Development and optimisation of an animal model for the study of ganglion cells in degenerative diseases of the retina and optic nerve.

Autores de IIS La Fe

• Anselmo Feliciano Sanchez

  Autor

• Romana Garcia Gil

  Autor

• Laura Cubas Núñez

  Autor

• Jéssica Castillo Villalba

  Autor

• Sara María García Gil-Perotín

  Autor

• José Manuel García Verdugo

  Autor

Participantes ajenos a IIS La Fe

• Fuentes-Maestre J
• Fil M

Grupos

• Investigación en Neuroinmunología y Esclerosis Múltiple

Abstract

Multiple sclerosis is an autoimmune, chronic and inflammatory disease of the central nervous system with axonal demyelination, gliosis and neurodegeneration. It is considered a frequent cause of neurological disability in young adults. In this work, an Experimental Autoimmune Encephalomyelitis (EAE) model was optimised by injecting a myelin oligodendrocyte glycoprotein (MOG 35-55 ). The ophthalmological effects were studied, as well as its use as an experimental model in other studies of retinal ganglion cell degeneration (RGC) and optic nerve (ON).

Keywords

• Células ganglionares de la retina, Encefalitis autoinmune experimental, Esclerosis múltiple, Experimental autoimmune encephalitis, Ganglion cells of the retina, Glicoproteína mielínica de los oligodendrocitos, Multiple sclerosis, Neuritis óptica, Oligodendrocyte myelin glycoprotein, Optic neuritis