Chromosomal Abnormalities and Prognosis in NPM1 -Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International Cohorts.

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Angenendt, L
  • Röllig C
  • Garcia, R
  • Botella, C
  • Martinez, P
  • Ravandi, F
  • Kadia, T
  • Kantarjian, HM
  • Cortes, J
  • Juliusson, G
  • Lazarevic, V
  • Höglund M
  • Lehmann, S
  • Recher, C
  • Pigneux, A
  • Bertoli, S
  • Dumas, PY
  • Dombret, H
  • Preudhomme, C
  • Micol, JB
  • Terre, C
  • Racil, Z
  • Novak, J
  • Žák P
  • Wei, AH
  • Tiong, IS
  • Wall, M
  • Estey, E
  • Shaw, C
  • Exeler, R
  • Wagenfuhr, L
  • Stölzel F
  • Thiede, C
  • Stelljes, M
  • Lenz, G
  • Mikesch, JH
  • Serve, H
  • Ehninger, G
  • Berdel, WE
  • Kramer, M
  • Krug, U
  • Schliemann, C

Grupos

Abstract

Nucleophosmin 1 ( NPM1 ) mutations are associated with a favorable prognosis in acute myeloid leukemia (AML) when an internal tandem duplication (ITD) in the fms-related tyrosine kinase 3 gene ( FLT3 ) is absent ( FLT3 -ITD neg ) or present with a low allelic ratio ( FLT3 -ITD low ). The 2017 European LeukemiaNet guidelines assume this is true regardless of accompanying cytogenetic abnormalities. We investigated the validity of this assumption.

Datos de la publicación

ISSN/ISSNe:
0732-183X, 1527-7755

JOURNAL OF CLINICAL ONCOLOGY  LIPPINCOTT WILLIAMS & WILKINS

Tipo:
Article
Páginas:
2632-2642
PubMed:
31430225
Factor de Impacto:
10,054 SCImago
Cuartil:
Q1 SCImago

Citas Recibidas en Web of Science: 98

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